Evidence map›Paper›PMID 39713289›Full record

ArticlebioRxiv : the preprint server for biology2024

Matrix Metalloproteinase-2 as a novel regulator of glucose utilization by adipocytes.

Melissa D Lempicki, Ryan J Garrigues, Tonya N Zeczycki, Brandon L Garcia, Thurl E Harris, Akshaya K Meher

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Melissa D LempickiDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, United States.
Ryan J GarriguesDepartment of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, United States.
Tonya N ZeczyckiDepartment of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, United States.
Brandon L GarciaDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, United States.
Thurl E HarrisDepartment of Pharmacology, University of Virginia, Charlottesville, VA 22903, United States.
Akshaya K MeherDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, United States.

Funding

BAFF 60mer as a novel therapeutic target for vascular diseasesR01HL146685 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHER, AKSHAYA KUMAR · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL146685
6 · The paper itself

Abstract

Glucose transporter 4 (GLUT4) expression on white adipocytes is critical for absorbing excess blood glucose, failure of which promotes hyperglycemia. Matrix metalloproteinases (MMPs) play a crucial role in remodeling the white adipose tissue (WAT) during obesity. MMPs have multiple protein substrates, and surprisingly, it is unknown if they can directly target GLUT4 on the adipocyte surface and impair glucose absorption. We identified MMP2 as the highly active gelatinase, a class of MMP, in the gonadal WAT of high-fat diet-induced obese mice.

Identifiers

PMID39713289
PMCPMC11661172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.