Evidence map›Paper›PMID 39713221›Full record

ArticleInternational journal of nanomedicine2024

Copper-Based Nanoparticles for Effective Treatment Against Sepsis-Induced Lung Injury in Mice Model.

Jie-Mei Li, Lu Zhang, Sheng-Lin Pei, Liang Guo, Hong-Lei Shen, Jing He, You-Yuan Guo, Wei-Qing Zhang, Fei Lin

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jie-Mei Li *Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Lu Zhang *Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Sheng-Lin PeiDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Liang GuoDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Hong-Lei ShenDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.ORCID 0009-0007-0787-2791
Jing HeDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
You-Yuan GuoDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Wei-Qing ZhangDepartment of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.
Fei LinDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, People's Republic of China.ORCID 0000-0002-7497-6159

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lung injury, a common complication of sepsis, arises from elevated reactive oxygen species (ROS), mitochondrial dysfunction, and cell death driven by inflammation. In this study, a novel class of ultrasmall nanoparticles (Cu Methods: The synthesized nanoparticles were thoroughly characterized to assess their properties. In vitro experiments were conducted to determine the biologically effective concentration and elucidate the anti-inflammatory mechanism of action. These findings were further supported by in vivo studies, showcasing the material's efficacy in mitigating SILI. Results: The Cu The conclusion: This study highlights the therapeutic potential of Cu

Indexed as

CopperDisease Models, AnimalLung InjuryMetal NanoparticlesReactive Oxygen SpeciesSepsisAnimalsAnti-Inflammatory AgentsAntioxidantsHydrogen PeroxideMaleMiceMice, Inbred C57BLOxidative StressSuperoxide DismutaseAnti-Inflammatory AgentsAntioxidantsCopperHydrogen PeroxideReactive Oxygen SpeciesSuperoxide Dismutaseanti-inflammationlung injurymitochondriareactive oxygen species scavengingultrasmall copper-based nanoparticles

Identifiers

PMID39713221
PMCPMC11662683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.