Evidence map›Paper›PMID 39713200›Full record

ReviewExploration (Beijing, China)2024

Innovative utilization of cell membrane-coated nanoparticles in precision cancer therapy.

Yiling He, Shuquan Zhang, Yaoguang She, Zhaoshan Liu, Yalan Zhu, Qinzhen Cheng, Xiaoyuan Ji

Abstract readReview
In one paragraph

Review in Exploration (Beijing, China), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  19. Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiling HeDepartment of Pharmacy Jinhua Municipal Central Hospital Jinhua Zhejiang China.
Shuquan ZhangDepartment of Orthopedics Integrated Chinese and Western Medicine Hospital Tianjin University Tianjin China.
Yaoguang SheDepartment of General Surgery First Medical Center Chinese People's Liberation Army (PLA) General Hospital Beijing China.
Zhaoshan LiuLaboratory of Immune Cell Biology Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda Maryland USA.
Yalan ZhuDepartment of Pharmacy Jinhua Municipal Central Hospital Jinhua Zhejiang China.
Qinzhen ChengDepartment of Pharmacy Jinhua Municipal Central Hospital Jinhua Zhejiang China.
Xiaoyuan JiAcademy of Medical Engineering and Translational Medicine Medical College Tianjin University Tianjin China.ORCID https://orcid.org/0000-0002-6768-2304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell membrane-coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. By encapsulating therapeutic agents within a cell membrane-derived coating, these nanoparticles combine the advantages of synthetic nanoparticles and natural cell membranes. This review provides a comprehensive overview of the recent advancements in utilizing CMNPs as effective drug delivery vehicles for cancer therapy. The synthesis and fabrication methods of CMNPs are comprehensively discussed. Various techniques, such as extrusion, sonication, and self-assembly, are employed to coat synthetic nanoparticles with cell membranes derived from different cell types. The cell membrane coating enables biocompatibility, reducing the risk of an immune response and enhancing the stability of the nanoparticles in the bloodstream. Moreover, functionalization strategies for CMNPs, primarily chemical modification, genetic engineering, and external stimuli, are highlighted. The presence of specific cell surface markers on the coated membrane allows targeted drug delivery to cancer cells and maximizes therapeutic efficacy. Preclinical studies utilizing CMNPs for cancer therapy demonstrated the successful delivery of various therapeutic agents, such as chemotherapeutic drugs, nucleic acids, and immunotherapeutic agents, using CMNPs. Furthermore, the article explores the future directions and challenges of this technology while offering insights into its clinical potential.

Indexed as

cancer therapycell membrane‐coated nanoparticlesnanomaterialstargeted drug delivery

Identifiers

PMID39713200
PMCPMC11655310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.