Evidence map›Paper›PMID 39713199›Full record

ArticleExploration (Beijing, China)2024

Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing.

Xiaoxue Li, Wei Wang, Qiuxia Gao, Shanshan Lai, Yan Liu, Sitong Zhou, Yan Yan, Jie Zhang, Huanhuan Wang, Jiamei Wang and 5 more

Erratum issuedAbstract read
In one paragraph

Article in Exploration (Beijing, China), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Trimetallic Zeolitic Imidazolate Framework-Derived CoNiOMolecules (Basel, Switzerland) · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Xiaoxue LiMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Wei WangMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Qiuxia GaoMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Shanshan LaiMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Yan LiuInstitute for Health Innovation and Technology National University of Singapore Singapore Singapore.
Sitong ZhouDepartment of Dermatology The First People's Hospital of Foshan Foshan Guangdong China.
Yan YanMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Jie ZhangMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Huanhuan WangMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Jiamei WangMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Yi FengMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.
Ronghua YangDepartment of Burn and Plastic Surgery Guangzhou First People's Hospital South China University of Technology Guangzhou Guangdong China.
Jianyu SuSchool of Food Science and Engineering South China University of Technology Guangzhou Guangdong China.
Bin LiSchool of Inspection Ningxia Medical University Yinchuan Ningxia China.ORCID https://orcid.org/0000-0001-9870-9963
Yuhui LiaoMolecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital of Southern Medical University Guangzhou Guangdong China.ORCID https://orcid.org/0000-0003-4702-9516

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infected burn wounds are characterized by persistent drug-resistant bacterial infection coupled with an inflammatory response, impeding the wound-healing process. In this study, an intelligent nanoparticle system (CCM+TTD@ZIF-8 NPs) was prepared using curcumin (CCM), an aggregation-induced emission luminogens (TTD), and ZIF-8 for infection-induced wound healing. The CCM+TTD@ZIF-8 NPs showed multiple functions, including bacteria targeting, fluorescence imaging and pH response-guided photodynamic therapy (PDT), and anti-inflammatory. The positive charges of ZIF-8 NPs allowed the targeting of drug-resistant bacteria in infected wounds, thereby realizing fluorescence imaging of bacteria by emitting red fluorescence at the infected site upon blue light irradiation. The pH-responsive characteristics of the CCM+TTD@ZIF-8 NPs also enabled controllable CCM release onto the infected wound site, thereby promoting the specific accumulation of ROS at the infected site, with outstanding bactericidal efficacy against drug-resistant

Indexed as

bacterial infection imagingmultifunctional therapeutic systempH‐responsivetargeting bacteriawound healing

Identifiers

PMID39713199
PMCPMC11655311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.