Evidence map›Paper›PMID 39713151›Full record

ArticlePeerJ2024

Prognostic value of inflammatory and nutritional indexes among patients with unresectable advanced gastric cancer receiving immune checkpoint inhibitors combined with chemotherapy-a retrospective study.

Meiqin Zhu, Lin-Ting Zhang, Wenjuan Lai, Fang Yang, Danyang Zhou, Ruilian Xu, Gangling Tong

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Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

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6citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Meiqin Zhu *Department of Medical Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Lin-Ting Zhang *Department of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Wenjuan LaiNursing Department, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Fang YangDepartment of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Danyang ZhouDepartment of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Ruilian XuDepartment of Medical Oncology, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Gangling TongDepartment of Oncology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent studies have revealed that inflammatory factors and nutritional status of patients with advanced gastric cancer (AGC) are related to the efficacy of drug therapy and patient prognosis. This study seeks to evaluate the correlation between inflammatory markers, nutritional status, and clinical outcomes of immune checkpoint inhibitor (ICI)-based therapies among inoperable AGC patients. Method: This retrospective study included 88 AGC patients who received ICIs combined with chemotherapy. Inflammatory and nutritional indicators from patients before and after two cycles of treatment were collected. Finally, the correlations between these indicators and the clinical response and survival of AGC patients with ICI treatment were examined. Results: The results revealed that an Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0, neutrophil count to lymphocyte count ratio (NLR) < 2.84, platelet count to lymphocyte count ratio (PLR) < 82.23, lymphocyte count to monocyte count ratio ≥ 2.35, the hemoglobin, albumin, lymphocyte and platelet score (HALP) ≥ 31.17, prognostic nutritional index (PNI) ≥ 46.53, albumin ≥ 41.65, the decreased HALP group and the decreased PNI group were significantly correlated with improved objective response rate. Additionally, an ECOG PS score of 0, NLR < 2.84 and the decreased HALP group was associated with a superior disease control rate. Meanwhile, an ECOG PS score of 0 (progression-free survival (PFS): Conclusion: Our study supports the potential of inflammatory and nutritional factors to serve as predictors of the efficacy and prognosis in patients undergoing ICI-based therapies for AGC. However, further investigations are necessary to validate these findings.

Indexed as

Immune Checkpoint InhibitorsNutritional StatusStomach NeoplasmsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsFemaleHumansInflammationLymphocyte CountMaleMiddle AgedNeutrophilsNutrition AssessmentPlatelet CountImmune Checkpoint InhibitorsAdvanced gastric cancerClinical responseImmune checkpoint inhibitorsInflammatory statusNutritional statusPrognosis

Identifiers

PMID39713151
PMCPMC11660861

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