Evidence map›Paper›PMID 39713051›Full record

ArticleFrontiers in endocrinology2024

Analysis of clinical and biochemical characteristics and left ventricular hypertrophy in patients with indeterminate saline infusion test results.

Huiyun Qu, Jingge Zhao, Lulu Wang, Huiyu Du, Qinghui Zhang, Tingxi Sun, Chen Zhang, Jiaxuan Chen, Linya Guo, Qi Huang and 4 more

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In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Huiyun QuDepartment of Hypertension, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China.
Jingge ZhaoClinical Research Centre, Henan Provincial People's Hospital, Zhengzhou, China.
Lulu WangDepartment of Hypertension, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Huiyu DuDepartment of Hypertension, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Qinghui ZhangDepartment of Hypertension, Henan Provincial People's Hospital, Zhengzhou, China.
Tingxi SunDepartment of Hypertension, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China.
Chen ZhangDepartment of Hypertension, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China.
Jiaxuan ChenDepartment of Hypertension, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Linya GuoDepartment of Hypertension, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Qi HuangDepartment of Hypertension, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.
Dandan TianDepartment of Hypertension, Henan Provincial People's Hospital, Zhengzhou, China.
Zhilan LiuDepartment of Hypertension, Henan Provincial People's Hospital, Henan University of Chinese Medicine, Zhengzhou, China.
Yibin HaoDepartment of Hypertension, Henan Provincial People's Hospital, Zhengzhou, China.
Min LiuDepartment of Hypertension, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The clinical biochemical characteristics and target organ damage (TOD) in patients with plasma aldosterone concentrations (PAC) ranging from 50 to 100 ng/L after a saline infusion test (SIT) have not been fully studied. Methods: A total of 611 hypertensive patients with an elevated aldosterone-to-renin ratio (ARR) who underwent a supine SIT at Henan Provincial People's Hospital were enrolled. The patients were divided into three groups according to their post-SIT PAC: <50 ng/L (control group), 50-100 ng/L (indeterminate post-SIT results group), and >100 ng/L (PA group). The clinical and biochemical characteristics and TOD of the three groups were compared. The correlation of the post-SIT PAC with left ventricular mass index (LVMI) was assessed via regression analysis. Results: The indeterminate post-SIT results group had the youngest patients and the shortest duration of hypertension. The prevalence of renal impairment (RI) and left ventricular hypertrophy (LVH) was lower than that in the PA group (P<0.05), but there was no statistically significant difference from the control group (P>0.05). After adjustment for confounders, the risk of developing carotid plaque was greater in the indeterminate post-SIT results group than in the control group (OR 1.73, 95% CI: 1.11, 2.69), and the prevalence of RI and LVH tended to increase with increasing post-SIT PAC levels. In multiple regression analyses, LVMI was significantly correlated with post-SIT PAC (P<0.05), but the basal PAC, plasma renin activity, and ARR did not significantly correlate with LVMI (P>0.05). Conclusion: A post-SIT PAC of 50-100 ng/L may be indicative of an early form of PA, and it may serve as an independent predictor of LVH, which could be related to the level of autonomously secreted aldosterone.

Indexed as

AldosteroneHypertensionHypertrophy, Left VentricularReninSaline SolutionAdultAgedFemaleHumansMaleMiddle AgedAldosteroneReninSaline Solutionautonomous aldosterone secretionleft ventricular hypertrophyprimary aldosteronismsaline infusion testtarget organ damage

Identifiers

PMID39713051
PMCPMC11658999

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.