Evidence map›Paper›PMID 39712953›Full record

ArticleGenetics in medicine open2024

iKNOW-Supporting the counseling of women with hereditary risk of breast and ovarian cancer with digital technologies: A randomized controlled trial.

Markus A Feufel, Dorothee Speiser, Stephen Schüürhuis, Konrad Neumann, Marie Keinert, Steffi Stegen, Gudrun Rauwolf, Maren Heibges, Viola Westfal, Laura Besch and 4 more

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In one paragraph

Article in Genetics in medicine open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Markus A FeufelDivision of Ergonomics, Department of Psychology and Ergonomics, Technische Universität Berlin, Berlin, Germany.
Dorothee SpeiserDepartment of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Stephen SchüürhuisInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Konrad NeumannInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Marie KeinertDepartment of Clinical Psychology and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen-Nuernberg, Germany.
Steffi StegenBRCA-Netzwerk e.V., Hilfe bei familiären Krebserkrankungen, Bonn, Germany.
Gudrun RauwolfInstitute of Vocational Education and Work Studies, Education for Sustainable Nutrition and Food Science, Technische Universität Berlin, Berlin, Germany.
Maren HeibgesDivision of Ergonomics, Department of Psychology and Ergonomics, Technische Universität Berlin, Berlin, Germany.
Viola WestfalInstitute of Sexology and Sexual Medicine, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
Laura BeschDepartment of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christine OlbrichDepartment of Gynecology with Breast Center, Hereditary Breast and Ovarian Cancer Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Katharina KleinGender in Medicine, Charité-Universitätsmedizin Berlin, Germany Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Isabell WitzelDepartment of Gynecology, University of Zurich, Switzerland.
Friederike KendelGender in Medicine, Charité-Universitätsmedizin Berlin, Germany Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: We developed the online-based counseling tool iKNOW for women with a pathogenic germline variant in Methods: With a randomized controlled trial, we investigated the efficacy of iKNOW with regard to risk understanding (primary endpoint), quality of life, risk perception, and anxiety (secondary endpoints). Self-report questionnaires were administered to Result: Deviations between self-assessed and calculated cancer risks tended to be smaller in the intervention group than in the control group but no longer significantly after adjustment for multiple testing. In the intervention group, the proportion of women with a correct understanding of breast cancer risk at T3 was higher (30.7% vs 14.7%; Conclusion: iKNOW tends to positively influence the understanding of familial cancer risk. At the same time, it does not negatively influence any of the secondary endpoints. However, converging evidence suggests that iKNOW seems to affect the quality of counseling processes and can thus be used as a paradigm for reinventing the notion of efficient, digital care.

Indexed as

Digital healthGenetic counselingGynecologyHereditary cancerRisk communication

Identifiers

PMID39712953
PMCPMC11658556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.