Evidence map›Paper›PMID 39712917›Full record

ArticleEFSA journal. European Food Safety Authority2024

Risk assessment of food contact materials.

Giorgia Maria Varalda, Sebastian Zellmer, Thomas Tietz

Abstract read
In one paragraph

Article in EFSA journal. European Food Safety Authority, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Risk assessment of food contact materials.EFSA journal. European Food Safety Authority · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giorgia Maria VaraldaItalian Institute of Health (ISS) Department of Environment and Health Rome Italy.
Sebastian ZellmerGerman Federal Institute for Risk Assessment (BfR) Department of Chemical and Product Safety - Safety of Food Contact Material Berlin Germany.
Thomas TietzGerman Federal Institute for Risk Assessment (BfR) Department of Chemical and Product Safety - Safety of Food Contact Material Berlin Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food Contact Materials (FCMs), such as plastics, papers, ceramics and inks used in food packaging, containers, kitchen utensils and tableware are subject to scrutiny due to their potential to release toxic compounds into food. In the European Union, materials and articles intended for contact with food must adhere to stringent safety regulations and novel materials not explicitly covered by existing legislation require individual risk assessment. This project focused on the assessment of the genotoxic potential of two substances used in FCMs, specifically neodecanoic acid (NDA) and di(2-ethylhexyl) phthalate (DEHP), for which data gaps have been identified in genotoxicity studies. NDA was selected because it was re-evaluated due to the intention to approve its use in printing inks for FCMs. For DEHP, various studies on genotoxicity are available, which, however, differ in their outcome. DEHP is commonly used as a plasticiser to enhance the flexibility, transparency, durability of plastics and is ubiquitously detected in daily life. The present study followed the EFSA strategy for the assessment of genotoxicity applying in vitro methods in bacterial and mammalian cells as well as in silico approaches. In this context, aneuploidy, a thresholded genotoxic effect, received particular attention since few indications are available on the aneugenic activity of FCMs. The results showed significant findings that require further investigation.

Indexed as

aneuploidyDEHPfood contact materialgenotoxicityneodecanoic acid

Identifiers

PMID39712917
PMCPMC11659736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.