ArticleFrontiers in public health2024
Analysis of risk factors for sepsis-related liver injury and construction of a prediction model.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Clinical efficacy and metabolomics profiling of dachaihu decoction for patients with septic liver injury: a randomized controlled trial.Frontiers in pharmacology · 2025Trial
- Sepsis in critically ill dogs: identification of clinical and laboratory risk factors and evaluation of sepsis scoring systems.Journal of veterinary internal medicine · 2026Article
- Aminotransferase-to-platelet Ratio Index for Sepsis-associated Liver Dysfunction: Promising Triage Signal but Phenotype Confounding and Implementation Calibration must be Intensive Care Unit Ready.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Secondary Hepatic Dysfunction in Critically Ill Children: Prognostic Associations Beyond PRISM III and PELOD-2 Scores.Journal of clinical medicine · 2026Article
- Sepsis-induced immunothrombosis: from cellular crosstalk to multiple organ dysfunction.Frontiers in immunology · 2026Review
- Multi-omics integration identifies ganoderic acid A as a TNFα inhibitor for treating sepsis-related liver injury.Frontiers in pharmacology · 2026Article
- Initial Aspartate Aminotransferase-to-platelet Ratio Index is Associated with Sepsis-associated Liver Dysfunction in Adult Patients with Sepsis: A Retrospective Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Carbon dioxide combining power as a predictor of unplanned ICU transfer in hospital wards: a retrospective cohort study.Frontiers in medicine · 2025Article
- A Practical Nomogram Based on RDW-CV for Predicting Clinical Outcome in Elderly Septic Patients.Infection and drug resistance · 2025Article
- DL-Tryptophan Alleviates Sepsis-Related Acute Liver Injury via AhR Activation.Journal of inflammation research · 2025Article
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Authors and funding
9 authors.
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Abstract
Background: Sepsis is a leading cause of mortality in critically ill patients, and the liver is a key organ affected by sepsis. Sepsis-related liver injury (SRLI) is an independent risk factor for multiple organ dysfunction syndrome (MODS) and mortality. However, there is no clear diagnostic standard for SRLI, making early detection and intervention challenging. Objective: This study aimed to investigate the predictive value of serum indices for the occurrence of SRLI in adults to guide clinical practice. Methods: In this study, we investigated the predictive value of serum indices for SRLI in adults. We retrospectively analyzed data from 1,573 sepsis patients admitted to West China Hospital, Sichuan University, from January 2015 to December 2019. Patients were divided into those with and without liver injury. Stepwise logistic regression identified independent risk factors for SRLI, and a predictive model was constructed. The model's diagnostic efficacy was assessed using receiver operating characteristic (ROC) curve analysis. Results: Our results showed that alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), carbon dioxide combining power (CO Conclusion: In conclusion, this study developed a highly accurate predictive model for SRLI using clinically accessible serum indicators, which could aid in early detection and intervention, potentially reducing mortality rates.
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