Evidence map›Paper›PMID 39712073›Full record

ArticleTherapeutic advances in medical oncology2024

Femoral bone metastasis is a poor prognostic factor in EGFR-TKIs-treated patients with

Ichidai Tanaka, Kazumi Hori, Junji Koyama, Soei Gen, Masahiro Morise, Yuta Kodama, Akira Matsui, Ayako Miyazawa, Tetsunari Hase, Yoshitaka Hibino and 5 more

Abstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ichidai TanakaDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.ORCID https://orcid.org/0000-0002-5517-0598
Kazumi HoriDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Junji KoyamaDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Soei GenDepartment of Respiratory Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
Masahiro MoriseDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuta KodamaDepartment of Respiratory Medicine, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan.
Akira MatsuiDepartment of Respiratory Medicine, Kariya Toyota General Hospital, Kariya, Japan.
Ayako MiyazawaDepartment of Respiratory Medicine, Konan Kosei Hospital, Konan, Japan.
Tetsunari HaseDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshitaka HibinoDepartment of Respiratory Medicine, Konan Kosei Hospital, Konan, Japan.
Toshihiko YokoyamaDepartment of Respiratory Medicine, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan.
Tomoki KimuraDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Japan.
Norio YoshidaDepartment of Respiratory Medicine, Kariya Toyota General Hospital, Kariya, Japan.
Mitsuo SatoDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Makoto IshiiDepartment of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Objectives: To analyze the association between bone metastatic sites and the clinical efficacy of the first-, second-, and third-generation EGFR-tyrosine kinase inhibitors (TKI), in these patients. Design: Retrospective multicenter cohort study. Methods: The clinical data of patients with advanced-NSCLC harboring Results: Bone metastases were found in 41.1% of the patients at diagnosis, including 13.1%, 8.0%, and 20.0 for single, double, and multiple lesions (⩾3), respectively. The vertebra (76.3%) and pelvis (60.9%) were the most frequent metastatic sites. Femoral-, sternum-, and scapula-metastases were remarkably increased in the patients with multiple-bone metastases. In the Conclusion: Femoral bone metastasis is associated with poor survival of

Indexed as

EGFR mutationEGFR-TKIsfemoral bone metastasismultiple-bone metastasesnon-small-cell lung cancerosimertinib

Identifiers

PMID39712073
PMCPMC11662391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.