Evidence map›Paper›PMID 39712018›Full record

ArticleFrontiers in immunology2024

Gene expression levels associated with impaired immune response and increased proliferation could serve as biomarkers for women following cervical cancer screening programmes.

Irene T Ovestad, Ingvild Dalen, Kristiane Soreng, Saleha Akbari, Morten Lapin, Emiel Am Janssen, Marie Austdal, Ane Cecilie Munk, Einar Gudlaugsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Irene T OvestadDepartment of Pathology, Stavanger University Hospital, Stavanger, Norway.
Ingvild DalenSection of Biostatistics, Department of Research, Stavanger University Hospital, Stavanger, Norway.
Kristiane SorengNational HPV Reference laboratory Department of Microbiology and Infection Control, Akershus University Hospital, Lørenskog, Norway.
Saleha AkbariDepartment of Pathology, Stavanger University Hospital, Stavanger, Norway.
Morten LapinDepartment of Haematology and Oncology, Stavanger University Hospital, Stavanger, Norway.
Emiel Am JanssenDepartment of Pathology, Stavanger University Hospital, Stavanger, Norway.
Marie AustdalSection of Biostatistics, Department of Research, Stavanger University Hospital, Stavanger, Norway.
Ane Cecilie MunkDepartment of Gynaecology, Sorlandet Hospital, Kristiansand, Norway.
Einar GudlaugssonDepartment of Pathology, Stavanger University Hospital, Stavanger, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human papilloma virus (HPV) infections vary in their oncogenic potential, and whether an infection progresses to cervical intraepithelial neoplasia (CIN) also depends on the immune response. Therefore, the aim of the present study was to explore biomarkers related to the immune system and cell proliferation, in combination with HPV classified as having high (HOP) or low oncogenic potential (LOP), that can possibly guide a more accurate identification of women following cervical cancer screening programmes in need for immediate follow-up with a biopsy. A next-generation sequencing transcriptomic immune profile analysis applied to 28 persistent CIN3 lesions and 14 normal biopsies identified four genes, the immune markers

Indexed as

Biomarkers, TumorEarly Detection of CancerPapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultCell ProliferationFemaleGene Expression ProfilingHumansMiddle AgedPapillomaviridaeTranscriptomeBiomarkers, Tumorbiomarkerscervical precancerHPVimmunologyNGSqPCRROC-AUC

Identifiers

PMID39712018
PMCPMC11659148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.