ArticleThe Pan African medical journal2024
[Effectiveness and tolerance of azathioprine as first-line treatment for multiple sclerosis: a case study from Morocco].
Article in The Pan African medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: the purpose of our study is to evaluate the efficacy of azathioprine as first-line treatment in patients with relapsing-remitting multiple sclerosis (RRMS) or progressive multiple sclerosis (PMS), who were supposed to be treated with beta-interferons but, due to limited resources, received azathioprine instead. Method: among the 31 patients, 17 had relapsing-remitting MS (RRMS), 11 had primary progressive MS (PPMS), and 3 had secondary progressive MS (SPMS). Patients received azathioprine orally at a dose of 3 mg/kg/day over 2 years. The effect of azathioprine was assessed using the Expanded Disability Status Scale (EDSS) score. Compare means t-test was used to determine the treatment performance. Results: for RRMS, the mean EDSS score ranged between 4.2 and 3.6±1.4. A total of 82.4% of patients were stable or improved, with a very highly significant difference (P= 0.000). For PPMS, the mean EDSS score remained constant at 5.7 ±0.4. A total of 54.5% of patients showed stability or improvement, with a highly significant difference (P= 0.005). In the case of SPMS, the mean EDSS score ranged between 4.5 and 4.1±1.3. A total of 66.7% of patients were stable or improved but with a non-significant difference (P= 0.1). Conclusion: the results of this study confirm that azathioprine is beneficial in the treatment of different types of multiple sclerosis in Morocco.
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