ArticlemedRxiv : the preprint server for health sciences2024
Performance and usability evaluation of three LDH-based malaria rapid diagnostic tests in Kédougou, Senegal.
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The emergence of Objectives: To evaluate the performance and usability of three LDH-based RDTs in febrile patients. Methods: A cross-sectional diagnostic accuracy study was conducted in Kédougou, Senegal. Capillary blood was tested using the SD Bioline Ag Pf (#05FK50) and three LDH-based RDTs: BIOCREDIT Malaria Ag Pf (pLDH), BIOCREDIT Pf (pLDH/HRPII), and BIOCREDIT Pf/Pv (pLDH/pLDH) (Rapigen Inc., Republic of Korea). Venous blood was collected to repeat the BIOCREDIT RDTs and conduct microscopy. Frozen venous specimens were tested using a reference PCR assay. A quantitative multiplex malaria antigen assay measured antigen concentration. RDT performance was determined and analyzed as a function of antigen concentration distribution. Usability of the Results: 154/220 participants (70%) were Conclusions: Both HRP2 and LDH contributed to the sensitivity of the best-performing
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