Evidence map›Paper›PMID 39711702›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Depression is Associated with Treatment Response Trajectories in Adults with Prolonged Grief Disorder: A Machine Learning Analysis.

Adam Calderon, Matthew Irwin, Naomi M Simon, M Katherine Shear, Christine Mauro, Sidney Zisook, Charles F Reynolds, Matteo Malgaroli

Registry-linked trialAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01179568 (Optimizing Treatment for Complicated Grief), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01179568 phase2completednot on this map

Optimizing Treatment for Complicated Grief (Healing Emotions After Loss:HEAL)

TypeinterventionalSponsorNew York State Psychiatric InstituteRan2010 to 2015Enrolled395ConditionsComplicated Grief, BereavementArmsCitalopram, Complicated Grief Treatment, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Adam CalderonDepartment of Psychiatry, New York University Grossman School of Medicine, New York, New York.ORCID 0000-0002-3968-0715
Matthew IrwinDepartment of Psychiatry, New York University Grossman School of Medicine, New York, New York.
Naomi M SimonDepartment of Psychiatry, New York University Grossman School of Medicine, New York, New York.ORCID 0000-0002-8867-889X
M Katherine ShearColumbia School of Social Work, Columbia University College of Physicians and Surgeons, New York, New York.ORCID 0000-0001-6163-1816
Christine MauroDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York.ORCID 0000-0001-6065-8128
Sidney ZisookDepartment of Psychiatry, University of California, San Diego.ORCID 0000-0003-3341-9185
Charles F ReynoldsDepartment of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-2605-7887
Matteo MalgaroliDepartment of Psychiatry, New York University Grossman School of Medicine, New York, New York.ORCID 0000-0003-4209-6939

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
RESEARCH TRAINING COREP60MD000207 · NIMHD · UNIV OF MARYLAND, COLLEGE PARK · PI THOMAS, STEPHEN B. · 2002 to 2011
$10.8M
RESEARCH METHODS COREP30MH090333 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEW, MARY AMANDA · 2011 to 2015
$8.3M
TRAUMATIC GRIEF TREATMENT--A RANDOMIZED CONTROLLED STUDYR01MH060783 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUAN, NAIHUA, SHEAR, M KATHERINE · 2000 to 2016
$4.0M
2/4-Optimizing Treatment of Complicated GriefR01MH085308 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SIMON, NAOMI M · 2009 to 2013
$2.0M
3/4-Optimizing Complicated Grief TherapyR01MH085288 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REYNOLDS, CHARLES F. · 2009 to 2013
$1.7M
4/4-Optimizing Treatment of Complicated GriefR01MH085297 · NIMH · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ZISOOK, SIDNEY · 2009 to 2013
$1.6M
Deep Learning Based Natural Language Processing Markers of Anxiety and DepressionK23MH134068 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Matteo Malgaroli · 2023 to 2026
$982k
NCATS NIH HHS UL1 TR000005NCRR NIH HHS UL1 RR024153NIMHD NIH HHS P60 MD000207NIMH NIH HHS K23 MH134068NIMH NIH HHS P30 MH090333NIMH NIH HHS R01 MH060783NIMH NIH HHS R01 MH085288NIMH NIH HHS R01 MH085297NIMH NIH HHS R01 MH085308
6 · The paper itself

Abstract

Although evidence-based treatments for Prolonged Grief Disorder (PGD) exist, pretreatment characteristics associated with differential improvement trajectories have not been identified. To identify clinical factors relevant to optimizing PGD treatment outcomes, we used unsupervised and supervised machine learning to study treatment effects from a double-blinded, placebo-controlled, randomized clinical trial. Participants were randomized into four treatment groups for 20 weeks: citalopram with grief-informed clinical management, citalopram with prolonged grief disorder therapy (PGDT), pill placebo with PGDT, or pill placebo with clinical management. The trial included 333 PGD patients aged 18-95 years ( Trial Registration: clinicaltrials.gov Identifier: NCT01179568.

Indexed as

citalopramGriefmachine learningtherapytrajectories

Identifiers

PMID39711702
PMCPMC11661326

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.