Evidence map›Paper›PMID 39711648›Full record

ArticleNeurophotonics2025

Early changes in spatiotemporal dynamics of remapped circuits and global networks predict functional recovery after stroke in mice.

Ryan M Bowen, Jake Lee, Brendon Wang, Keith R Lohse, Hanyang Miao, Jonah A Padawer-Curry, Asher J Albertson, Eric C Landsness, Adam Q Bauer, Jin-Moo Lee

Abstract read
In one paragraph

Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Slow Oscillations Track Acute Stroke Injury but Not Functional Recovery.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryan M BowenWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.ORCID https://orcid.org/0000-0003-0970-3581
Jake LeeWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.
Brendon WangWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.ORCID https://orcid.org/0009-0009-6441-824X
Keith R LohseWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.
Hanyang MiaoWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.ORCID https://orcid.org/0000-0001-5757-859X
Jonah A Padawer-CurryWashington University in St. Louis, Imaging Sciences PhD Program, St. Louis, Missouri, United States.ORCID https://orcid.org/0000-0003-0275-1468
Asher J AlbertsonWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.
Eric C LandsnessWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.
Adam Q BauerWashington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States.
Jin-Moo LeeWashington University in St. Louis, Department of Neurology, St. Louis, Missouri, United States.ORCID https://orcid.org/0000-0002-3979-0906

Funding

Plasticizing the Cortex to Enhance Stroke RecoveryR37NS110699 · NINDS · WASHINGTON UNIVERSITY · PI LEE, JIN-MOO · 2019 to 2025
$3.5M
Integrating TPM and PAM to examine the metabolic underpinning of neurovascular repair after strokeR01NS120481 · NINDS · WASHINGTON UNIVERSITY · PI HU, SONG, LEE, JIN-MOO · 2021 to 2025
$3.1M
Mid-America Regional Coordinating Center (MARCC)U24NS107230 · NINDS · WASHINGTON UNIVERSITY · PI Andria Lee Ford, Peter David Panagos · 2018 to 2026
$2.8M
OPTOGENETIC MAPPING OF CELL SPECIFIC CONNECTIONS IN THE MOUSE BRAIN AFTER STROKER01NS102870 · NINDS · WASHINGTON UNIVERSITY · PI BAUER, ADAM Q · 2018 to 2022
$2.1M
Determining the efficacy of therapeutic interventions after stroke from cell specific functional connectomesR01NS126326 · NINDS · WASHINGTON UNIVERSITY · PI ADAM Q BAUER · 2023 to 2026
$1.8M
Role of Axonal Sprouting Mediated Network Reorganization in Stroke RecoveryK08NS117888 · NINDS · WASHINGTON UNIVERSITY · PI Asher Jefferson Albertson · 2022 to 2026
$993k
Local slow wave sleep in repair and recovery after strokeK08NS109292 · NINDS · WASHINGTON UNIVERSITY · PI LANDSNESS, ERIC C · 2020 to 2024
$943k
The Influence of Arc on Remapping, Network Repair, and Functional Recovery After StrokeF31NS122499 · NINDS · WASHINGTON UNIVERSITY · PI BOWEN, RYAN · 2022 to 2023
$94k
NINDS NIH HHS F31 NS122499NINDS NIH HHS K08 NS109292NINDS NIH HHS K08 NS117888NINDS NIH HHS R01 NS102870NINDS NIH HHS R01 NS120481NINDS NIH HHS R01 NS126326NINDS NIH HHS R37 NS110699NINDS NIH HHS U24 NS107230
6 · The paper itself

Abstract

Significance: Stroke is the leading cause of chronic disability in the United States. How stroke size affects post-stroke repair and recovery is poorly understood. Aim: We aim to investigate the effects of stroke size on early repair patterns and determine how early changes in neuronal circuits and networks predict functional outcomes after stroke. Approach: We used wide-field optical imaging, photothrombosis, and the cylinder-rearing assay to examine changes in neuronal circuit and network activity in the context of functional recovery after stroke. Results: Larger strokes ablating Conclusions: These results suggest that diffuse patterns of remapping, and desynchronization and hyperconnectivity of cortical networks, evolving early after stroke may reflect maladaptive plasticity, predicting poor long-term functional recovery.

Indexed as

brain network repairremappingstrokestroke recoverystroke size

Identifiers

PMID39711648
PMCPMC11661640

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.