Evidence map›Paper›PMID 39711602›Full record

ArticleBiologics : targets & therapy2024

The Association Between the rs2200733 SNP and Atrial Fibrillation Among Arabs: A Study from Jordan.

Abdullah H Al-Kasasbeh, Omar F Khabour, Rowida Almomani, Muhannad Ababneh, Rashid Ibdah, Mohamad Ismail Jarrah, Sukaina I Rawashdeh, Abdelsamea Mohammed Seif

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Article in Biologics : targets & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Abdullah H Al-KasasbehDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Omar F KhabourDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.ORCID 0000-0002-3006-3104
Rowida AlmomaniDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Muhannad AbabnehDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.ORCID 0000-0001-8193-7046
Rashid IbdahDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.ORCID 0000-0001-7872-973X
Mohamad Ismail JarrahDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.ORCID 0000-0003-4218-7128
Sukaina I RawashdehDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.ORCID 0000-0002-9902-5667
Abdelsamea Mohammed SeifDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.ORCID 0000-0003-3914-0126

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Atrial fibrillation (AFib) is a common disorder featured by an irregular and fast heartbeat. The etiology of AFib is complex and involves genetic and environmental factors. The rs2200733 single nucleotide polymorphism (SNP) is located in close proximity to the promoter of paired-like homeodomain transcription factor 2 (PITX2) which plays a role in heart development. Objective: In this study, the association between the rs2200733 SNP and AFib was examined in the Jordanian population. Methods: The study included 450 subjects (274 controls and 176 patients with AFib). Patients were recruited from King Abdullah University Hospital based on the European Society of Cardiology criteria. The rs2200733 SNP was genotyped using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique. Results: The mutant T allele of the rs2200733 SNP was common in the studied population with a frequency of 19%. The T allele and CT/TT genotypes were prevalent among patients with AFib compared with the controls (P<0.05, OR [CI]: 1.65 [1.12-2.43]). In addition, body mass index, diabetes, and hypertension were found to be associated with AFib risk. Conclusion: The rs2200733 SNP was associated with AFib among Jordanian patients. The mutant T allele of the rs2200733 SNP might increase the risk of AFib.

Indexed as

Arabsatrial fibrillationJordanPITX2RFLPrs2200733

Identifiers

PMID39711602
PMCPMC11662922

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