Evidence map›Paper›PMID 39711563›Full record

ArticleResearch square2024

Restoring Mitochondrial Quantity and Quality to Reverse Warburg Effect and Drive Tumor Differentiation.

Jiangbin Ye, Haowen Jiang, Sarah Tiche, Clifford He, Junyan Liu, Fuyun Bian, Mohamed Jedoui, Balint Forgo, Md Tauhidul Islam, Meng Zhao and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Jiangbin YeStanford University.ORCID https://orcid.org/0000-0003-1117-4869
Haowen JiangStanford University.
Sarah TicheStanford University.
Clifford HeUC San Diego School of Medicine.ORCID https://orcid.org/0000-0003-4855-5171
Junyan LiuStanford University.
Fuyun BianStanford University.
Mohamed JedouiStanford University.
Balint ForgoStanford University.
Md Tauhidul IslamStanford University.ORCID https://orcid.org/0000-0001-6259-632X
Meng ZhaoStanford University.ORCID https://orcid.org/0000-0002-5415-8335
Pamela EmengoStanford University.
Bo HeStanford University.
Yang LiStanford University.ORCID https://orcid.org/0000-0002-1914-5598
Albert LiStanford University.
Anh TruongAgilent Technologies.
Jestine HoAgilent Technologies.
Cathyrin SimmermakerAgilent Technologies.
Yanan YangAgilent Technologies.
Meng-Ning ZhouStanford University.
Zhen HuStanford University.
Katrin SvenssonStanford University.
Daniel CuthbertsonAgilent Technologies.
Florette HazardUC Davis.ORCID https://orcid.org/0000-0002-1538-0937
Lei XingStanford University.ORCID https://orcid.org/0000-0003-2536-5359
Hiroyuki ShimadaStanford University.
Bill ChiuStanford University.

Funding

Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesisK99AR081618 · NIAMS · STANFORD UNIVERSITY · PI ZHAO, MENG · 2023 to 2024
$182k
NIAMS NIH HHS K99 AR081618
6 · The paper itself

Abstract

Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors, and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and inhibits proliferation. U-

Identifiers

PMID39711563
PMCPMC11661309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.