Evidence map›Paper›PMID 39711526›Full record

ArticleResearch square2024

Unique structural features in a deep-sea CYP51 relate to high pressure adaptation.

Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, George Minasov, Jared V Goldstone, Steven L Kelly, John Stegeman, Galina I Lepesheva

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Tatiana Y HargroveDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
David C LambFaculty of Medicine, Health and Life Science, Swansea University, Swansea, SA2 8PP, UK.
Zdzislaw WawrzakNorthwestern University, Argonne, IL, 60439, USA.
George MinasovNorthwestern University, Argonne, IL, 60439, USA.
Jared V GoldstoneBiology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA.ORCID https://orcid.org/0000-0002-9618-4961
Steven L KellyFaculty of Medicine, Health and Life Science, Swansea University, Swansea, SA2 8PP, UK.ORCID https://orcid.org/0000-0001-7991-5040
John StegemanBiology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA.ORCID https://orcid.org/0000-0001-8204-5357
Galina I LepeshevaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.ORCID https://orcid.org/0000-0002-6975-1131

Funding

Structural requirements for sterol 14α-demethylasesR35GM151876 · NIGMS · VANDERBILT UNIVERSITY · PI Galina I Lepesheva · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM151876
6 · The paper itself

Abstract

Cytochromes P450 (CYP) form one of the largest enzyme superfamilies on Earth, with similar structural fold but biological functions varying from synthesis of physiologically essential compounds to metabolism of myriad xenobiotics. Here we determined the crystal structures of

Identifiers

PMID39711526
PMCPMC11661291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.