Evidence map›Paper›PMID 39711476›Full record

ArticleInnate immunity2024

Circulating MiR-126 as a potential biomarker in Egyptian colorectal cancer patients: A case-control study.

Rasha Ahmed Ghorab, Shaimaa H Fouad, Ahmed F Sherief, Rana M Taha, Marwa Hamdy, Mohammad M Darwish, Eman M El-Sehsah, Sara I Taha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rasha Ahmed GhorabDepartment of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Shaimaa H FouadDepartment of Internal Medicine/Allergy and Clinical Immunology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.ORCID 0000-0003-4052-9454
Ahmed F SheriefDepartment of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Rana M TahaDepartment of Geriatrics Medicine and Gerontology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Marwa HamdyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohammad M DarwishDepartment of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eman M El-SehsahDepartment of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt.
Sara I TahaDepartment of Clinical Pathology, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.ORCID 0000-0001-8224-8701

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlobally, colorectal cancer (CRC) is among the most prevalent malignant tumors. It is characterized by unlimited proliferation, invasion, and metastasis. MicroRNA-126 (miR-126) has been shown in many studies to play a significant role in CRC, but data regarding its role in CRC Egyptian patients are limited.

objectivesThis case-control study aimed to investigate the miR-126 as a potential marker in CRC Egyptian patients and to correlate its expression levels with CRC tumor, node, metastasis (TNM) stage, distant metastasis, and tumor size.

methodsThe study included 50 adult Egyptian participants (30 patients with CRC, 10 patients with colorectal adenoma as a pathological control, and 10 healthy controls). MiR-126 expression levels were detected using Real-Time Quantitative PCR (qPCR) along with the endogenous reference gene hsa-miR-103a in all participants.

resultsMiR-126 expression was significantly decreased in CRC patients than both control groups. It was associated with advanced TNM stage (

conclusionsOur results suggest that miR-126 could be used as an early marker for CRC detection among Egyptian patients and a good prognostic indicator associated with metastasis.

Indexed as

Colorectal cancerEgyptianmetastasisMiR-126prognosistumor size

Identifiers

PMID39711476
PMCPMC11664558

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.