Evidence map›Paper›PMID 39711458›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

A whole-brain functional connectivity model of Alzheimer's disease pathology.

Ruchika S Prakash, Michael R McKenna, Oyetunde Gbadeyan, Anita R Shankar, Erika A Pugh, James Teng, Rebecca Andridge, Anne Berry, Douglas W Scharre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. A whole-brain functional connectivity model of Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  6. The Role of Visual Experience in Individual Differences of Brain Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruchika S PrakashDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Michael R McKennaDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Oyetunde GbadeyanDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Anita R ShankarDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Erika A PughDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
James TengDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Rebecca AndridgeDivision of Biostatistics, The Ohio State University, Columbus, Ohio, USA.
Anne BerryDepartment of Psychology, Brandeis University, Waltham, Massachusetts, USA.
Douglas W ScharreDepartment of Neurology, Division of Cognitive Neurology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Mindfulness Training for Mitigating Age-Related Cognitive Decline in the ElderlyR01AG054427 · NIA · OHIO STATE UNIVERSITY · PI PRAKASH, RUCHIKA SHAURYA · 2017 to 2021
$2.2M
National Institute On Aging of the National Institutes of Health R01AG054427NCATS NIH HHS UL1 TR002733NCATS NIH HHS UL1TR002733NIA NIH HHS R01 AG054427
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) is characterized by the presence of two proteinopathies, amyloid and tau, which have a cascading effect on the functional and structural organization of the brain.

methodsIn this study, we used a supervised machine learning technique to build a model of functional connections that predicts cerebrospinal fluid (CSF) p-tau/Aβ

resultsWe successfully derived the PATH-fc model to predict the ratio of p-tau/Aβ DISCUSSION: Our pathology-based model of functional connectivity included representation from multiple canonical networks of the brain with intra-network connectivity associated with low pathology and inter-network connectivity associated with higher levels of pathology. HIGHLIGHTS: Whole-brain functional connectivity model (PATH-fc) is linked to AD pathophysiology. The PATH-fc model predicts performance in multiple domains of cognitive functioning. The PATH-fc model is a distributed model including representation from all canonical networks.

Indexed as

Alzheimer DiseaseBrainModels, NeurologicalAgedAged, 80 and overAmyloid beta-PeptidesFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragmentstau Proteinscognitionconnectome‐based predictive modelingdistributed networksfunctional connectivityresting‐state

Identifiers

PMID39711458
PMCPMC11781256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.