Evidence map›Paper›PMID 39711285›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life.

Kejal Kantarci, Ekta Kapoor, Jennifer R Geske, Anna Castillo, Julie A Fields, Firat Kara, Evdokiya E Knyazhanskaya, Christopher G Schwarz, Matthew L Senjem, Kent R Bailey and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03821857 (Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03821857 phase4recruitingnot on this map

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease

TypeinterventionalSponsorMayo ClinicRan2019 to 2030Enrolled614ConditionsAlzheimer DiseaseArms18-F-Flortaucipir
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kejal KantarciDepartment of Radiology, Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota, USA.
Ekta KapoorMayo Clinic Women's Health Research Center, Mayo Clinic, Rochester, Minnesota, USA.
Jennifer R GeskeDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Anna CastilloDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Firat KaraDepartment of Radiology, Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota, USA.
Evdokiya E KnyazhanskayaMayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Christopher G SchwarzDepartment of Radiology, Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota, USA.
Matthew L SenjemDepartment of Radiology, Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota, USA.
Kent R BaileyDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Val LoweDepartment of Radiology, Division of Neuroradiology, Mayo Clinic, Rochester, Minnesota, USA.
Nathan K LeBrasseurDepartment of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
Walter A RoccaMayo Clinic Women's Health Research Center, Mayo Clinic, Rochester, Minnesota, USA.
Michelle M MielkeDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M · 2018 to 2022
$7.7M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
NIA NIH HHS R33 AG058738NIA NIH HHS U54 AG044170NIH HHS RF1 AG577547NIH HHS U54 AG044170
6 · The paper itself

Abstract

introductionPremenopausal bilateral oophorectomy (PBO) before the age of 46 years is associated with an increased risk of dementia. We investigated the long-term effects of PBO performed before age 50 years on amyloid beta (Aβ), tau, and neurodegeneration imaging biomarkers of Alzheimer's disease (AD).

methodsMayo Clinic Cohort Study of Oophorectomy and Aging-2 participants were divided into early PBO (< 46 years; n = 61), and late PBO (46-49 years; n = 51) groups and were compared to referent women who did not undergo PBO (n = 119).

resultsEarly PBO was associated with thinner entorhinal cortex (p = 0.014), higher tau load at higher levels of Aβ load (Pp = 0.005), higher Aβ load (p = 0.026), and smaller temporal lobe cortical thickness (p = 0.022), only at older ages compared to the referent group. DISCUSSION: PBO before the age of 46 years is associated with entorhinal cortex thinning, elevated tau at higher Aβ levels, along with an AD-like pattern of atrophy at older ages. CLINICAL TRIALS REGISTRATION: NCT03821857 sex-specific effects of endocrine disruption on aging and AD. HIGHLIGHTS: Premenopausal bilateral oophorectomy (PBO) before the ages of 46 (early PBO) years and ages 46 to 49 (late PBO) years was studied. Early PBO was associated with reduced entorhinal cortex thickness later in life. Early PBO was associated with greater amyloid beta (Aβ) load at older ages. Early PBO was associated with greater Alzheimer's disease pattern of atrophy at older ages. Early PBO was associated with higher tau load at higher Aβ levels.

Indexed as

Alzheimer DiseaseOvariectomyPremenopauseAgedAmyloid beta-PeptidesBiomarkersCohort StudiesEntorhinal CortexFemaleHumansMagnetic Resonance ImagingMiddle Agedtau ProteinsTemporal LobeAmyloid beta-PeptidesBiomarkerstau Proteinsamyloidatrophymagnetic resonance imagingmenopauseoophorectomypositron emission tomographypremenopausal oophorectomytau

Identifiers

PMID39711285
PMCPMC12226247

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.