Evidence map›Paper›PMID 39711202›Full record

ArticleObesity (Silver Spring, Md.)2025

Siesta behavior and genetics interact to influence obesity risk.

María Rodríguez-Martín, Diego Salmerón, Hassan S Dashti, Ana Isabel Cascales, Aurora Aragón-Alonso, Frank A J L Scheer, Richa Saxena, Marta Garaulet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

María Rodríguez-MartínDepartment of Physiology, University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-9877-7728
Diego SalmerónBiomedical Research Institute of Murcia, IMIB Arrixaca, University of Murcia, University Clinical Hospital, Murcia, Spain.ORCID https://orcid.org/0000-0002-4574-6880
Hassan S DashtiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-1650-679X
Ana Isabel CascalesDepartment of Physiology, University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-2204-7534
Aurora Aragón-AlonsoEndocrinology and Nutrition Service, Clinical University Hospital Virgen Arrixaca, Murcia, Spain.ORCID https://orcid.org/0000-0003-4507-9210
Frank A J L ScheerDivision of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2014-7582
Richa SaxenaDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-2233-1065
Marta GarauletDepartment of Physiology, University of Murcia, Murcia, Spain.ORCID https://orcid.org/0000-0002-4066-3509

Funding

Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A, TAVAKKOLI, ALI · 2017 to 2023
$4.2M
Food Timing to Mitigate Adverse Consequences of Night WorkR01HL153969 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2021 to 2025
$3.9M
NHLBI NIH HHS R01 HL140574NHLBI NIH HHS R01 HL153969NIH HHS R01 HL140574NIH HHS R01 HL153969Spanish Ministry of Science and Innovation (MCINN) PID2020-112768RB-I00
6 · The paper itself

Abstract

objectiveIn this cross-sectional study, we aim to investigate the interactions between obesity, siesta behavior, and the genetic propensity for siesta in a Mediterranean population, in whom siesta is deeply rooted.

methodsWe applied a previously generated Siesta-Polygenic Score (PGS) in the ONTIME study (n = 1278). Siesta and other Mediterranean lifestyle behaviors were characterized using questionnaires. We further determined obesity grade. Secondarily, we measured weight loss during treatment as well as long-term weight-loss maintenance. Logistic regression analyses were performed to address our aim.

resultsA total of 42.4% of the population usually took siesta. A significant genetic influence on siesta propensity was found, with a higher genetic predisposition linked to taking siesta more frequently (odds ratio [OR] = 1.17, 95% CI: 1.03-1.32; p = 0.015). Participants with a higher genetic propensity for siesta showed poorer dietary habits (p < 0.05). Among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have lower odds of having obesity (p = 0.038) compared with those who do not. Similarly, in exploratory analysis, among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have higher odds of weight-loss success (p = 0.007) compared with those who do not.   

conclusionsConsidering the ongoing debate regarding whether siesta is beneficial or detrimental, our findings suggest that individual genetic predisposition to siesta might influence the association between siesta and health.

Indexed as

Genetic Predisposition to DiseaseObesityAdultAgedCross-Sectional StudiesDiet, MediterraneanFeeding BehaviorFemaleHumansLife StyleMaleMiddle AgedRisk FactorsSurveys and QuestionnairesWeight Loss

Identifiers

PMID39711202
PMCPMC11664305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.