Evidence map›Paper›PMID 39711146›Full record

ArticleCancer2025

Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Timothy Nguyen, Alzina Koric, Chun-Pin Esther Chang, Christine Barul, Loredana Radoi, Diego Serraino, Mark P Purdue, Karl T Kelsey, Michael D McClean, Eva Negri and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The global, regional, and national disease burden of laryngeal cancer attributable to high alcohol use from 1990 to 2021: a global burden of disease study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  2. Coffee as a Source of Antioxidants and an Elixir of Youth.Antioxidants (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Timothy NguyenDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0009-0009-1571-8959
Alzina KoricDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.ORCID https://orcid.org/0009-0003-9943-2945
Chun-Pin Esther ChangDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-0878-997X
Christine BarulUniv Rennes, INSERM, EHESP, Institut de recherche en sante, environnement et travail-UMR_S 1085, Pointe-a-Pitre, France.
Loredana RadoiUniversité Paris-Saclay, UVSQ, Université Paris Cité, Inserm, Gustave Roussy, Centre for Research in Epidemiology and Population Health, Villejuif, France.
Diego SerrainoEpidemiology and Biostatistics Unit, CRO Aviano National Cancer Institute, Aviano, Italy.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-1177-3108
Karl T KelseyBrown University, Providence, Rhode Island, USA.
Michael D McCleanBoston University School of Public Health, Boston, Massachusetts, USA.
Eva NegriDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Valeria EdefontiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Kirsten MoysichRoswell Park Cancer Institute, Buffalo, New York, USA.ORCID https://orcid.org/0000-0002-4678-2058
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan, USA.
Fabio LeviDepartment of Epidemiology and Health Services Research, Centre for Primary Care and Public Health (Unisanté), Univesity of Lausanne, Lausanne, Switzerland.
Thomas L VaughanFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Carlo La VecchiaDepartment of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Werner GaravelloDepartment of Otorhinolaryngology, School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Richard B HayesDivision of Epidemiology, New York University School of Medicine, New York, New York, USA.
Simone BenhamouNational Institute of Health and Medical Research, Inserm U1018, Villejuif, France.
Stimson P SchantzNew York Eye and Ear Infirmary, New York, New York, USA.
Guo-Pei YuDepartment of Otolaryngology, School of Medicine, New York Medical College, Valhalla, New York, USA.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Shu-Chun ChuangInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli, Taiwan.ORCID https://orcid.org/0000-0002-1190-5687
Paolo BoffettaDepartment of Family, Population and Preventive Medicine, Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York, USA.ORCID https://orcid.org/0000-0002-3811-2791
Mia HashibeDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Yuan-Chin Amy LeeDivision of Public Health, Department of Family & Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Funding

UCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0M
UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
The Boston Collaborative Oral Cancer StudyR01CA078609 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 1999 to 2010
$5.3M
LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1M
Postdoctoral Training in Cancer Prevention and ControlT32CA190194 · NCI · WASHINGTON UNIVERSITY · PI GRAHAM A. COLDITZ, AIMEE S JAMES · 2014 to 2026
$4.7M
Patterns of Somatic Gene Alterations in Oral CancerR01CA100679 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KELSEY, KARL TIMOTHY · 2004 to 2012
$2.6M
MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1999 to 2003
$1.8M
Molecular Epidemiology and Gene-Environment InteractionR21ES011667 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 2002 to 2004
$651k
Pooled Analyses of SNPs and Risk of Head &Neck CancerR03DE016611 · NIDCR · INTERNATIONAL AGENCY FOR RES ON CANCER · PI HASHIBE, MIA · 2005 to 2006
$223k
International Head and Neck Cancer ConsortiumR03CA113157 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI HASHIBE, MIA · 2004 to 2005
$118k
HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCERR03CA077954 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1997 to 1998
–
ALCOHOL AND CANCERS OF THE LARYNX AND ESOPHAGUSR01CA030022 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMAS, DAVID DALE · 1985 to 1987
–
NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA030022NCI NIH HHS R01 CA078609NCI NIH HHS R01 CA100679NCI NIH HHS R03 CA077954NCI NIH HHS R03 CA113157NCI NIH HHS T32 CA009142NCI NIH HHS T32CA009142NCI NIH HHS T32 CA190194NCI NIH HHS T32CA190194NCI NIH HHS U01 CA096134NIDA NIH HHS R01 DA011386NIDCR NIH HHS R03 DE016611NIEHS NIH HHS R21 ES011667
6 · The paper itself

Abstract

introductionThe relations between coffee and tea consumption and head and neck cancer (HNC) incidence are unclear. With increasing global HNC burden, this study aims to examine the association between coffee, tea, and HNC.

methodsA pooled analysis of 9548 HNC cases and 15,783 controls from 14 individual-level case-control studies was conducted from the International Head and Neck Cancer Epidemiology consortium. Random-effects logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for HNC and its subsites, adjusting for sociodemographic and lifestyle factors.

resultsCompared to non-coffee drinkers, drinking >4 cups of caffeinated coffee daily was inversely associated with HNC (OR, 0.83; 95% CI, 0.69-1.00), oral cavity (OR, 0.70; 95% CI, 0.55-0.89), and oropharyngeal cancers (OR, 0.78; 95% CI, 0.61-0.99). Drinking 3-4 cups of caffeinated coffee was inversely associated with hypopharyngeal cancer (OR, 0.59; 95% CI, 0.39-0.91). Drinking decaffeinated coffee and drinking between >0 to <1 cup daily were inversely associated with oral cavity cancer (OR, 0.75; 95% CI, 0.64-0.87 and OR, 0.66; 95% CI, 0.54-0.81). Drinking tea was inversely associated with hypopharyngeal cancer (OR, 0.71; 95% CI, 0.59-0.87). Daily tea consumption of >0 to ≤1 cup was inversely associated with HNC (OR, 0.91; 95% CI, 0.84-0.98) and hypopharyngeal cancer (OR, 0.73; 95% CI, 0.59-0.91), but drinking >1 cup was associated with laryngeal cancer (OR, 1.38; 95% CI, 1.09-1.74).

conclusionThese findings support reduced HNC risk among coffee and tea drinkers. Future studies are needed to address geographical differences in types of coffee and tea to improve our understanding of the association of coffee and tea and global HNC risk.

Indexed as

CoffeeHead and Neck NeoplasmsTeaAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedOdds RatioRisk FactorsCoffeeTeacoffee and teahead and neck cancerpooled analysis

Identifiers

PMID39711146
PMCPMC11733827

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.