ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Association between vascular risk factors and white matter integrity among diverse predominantly older Hispanic/Latino adults from the SOL-INCA MRI study.GeroScience · 2026Article
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Regional juxtacortical microstructural changes and gene expression provide insights into neurodegeneration in Alzheimer's disease.Translational psychiatry · 2026Article
- Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome-associated Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Free water changes and their correlations with multimodal biomarkers in frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Brain volume trajectories in young children are associated with polygenic scores for late-onset Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- White matter microstructural and macrostructural profiles during midlife reveal sex differences between men and women at different menopausal stages.Scientific reports · 2025Article
- A new ANMerge-based blood transcriptomic resource to support Alzheimer's disease research.medRxiv : the preprint server for health sciences · 2025Article
- White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.JAMA neurology · 2025Article
- The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Longitudinal effects of sex differences and apolipoprotein E genotype on white matter engagement among elderly.Brain communications · 2025Article
- Article
- Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cerebrospinal fluid YKL-40 relates to white matter hyperintensity progression in females but not males over a 6-year period.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
- Update ofSex, racial, and2024
Authors and funding
48 authors.
Amalia PetersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-7015-7957
Aditi SatheVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Dimitrios ZarasVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Yisu YangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Alaina DurantVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kacie D DetersDepartment of Integrative Biology and Physiology, University of California, Los Angeles, California, USA.
Niranjana ShashikumarVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kimberly R PechmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Michael E KimDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Chenyu GaoDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Nazirah Mohd KhairiDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Zhiyuan LiDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Tianyuan YaoDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Yuankai HuoDepartment of Computer Science, Vanderbilt University, Nashville, Tennessee, USA.
Logan DumitrescuVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Katherine A GiffordVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jo Ellen WilsonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Francis E CambroneroVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Shannon L RisacherDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lori L Beason-HeldLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Yang AnLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Guray ErusDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christos DavatzikosDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Duygu TosunDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Arthur W TogaLaboratory of Neuroimaging, USC Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
Elizabeth C MorminoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
Mohamad HabesNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Di WangNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Panpan ZhangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Kurt SchillingDepartment of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alzheimer's Disease Neuroimaging Initiative (ADNI)
BIOCARD Study Team
Alzheimer's Disease Sequencing Project (ADSP)
Marilyn AlbertDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Walter KukullNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Sarah A BiberNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Bennett A LandmanDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Julie SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Angela L JeffersonVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Susan M ResnickLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Derek B ArcherVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Funding
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MTHERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2MVIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4MWASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1MProject 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI JUAN TRONCOSO · 2014 to 2026
$51.5MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MSatellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MAlzheimer's Association IIRG-08-88733(ALJ)BAL R01-EB017230DBA K01-AG073584Intramural NIH HHS 75N95D22P00141NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NIA NIH HHS K01 AG073584NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG034962NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG054047NIA NIH HHS R01 AG056405NIA NIH HHS R01 AG056534NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG062826NIA NIH HHS R01 AG064233NIA NIH HHS R01 AG067482NIA NIH HHS R01 AG068193NIA NIH HHS R01 AG073439NIA NIH HHS R01 AG080821NIA NIH HHS R01 AG083865NIA NIH HHS R01 AG085571NIA NIH HHS R56 AG037639NIA NIH HHS RF1 AG054047NIA NIH HHS T32 AG058524NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG033655NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIBIB NIH HHS K01 EB032898NIBIB NIH HHS R01 EB017230NICHD NIH HHS P50 HD103537NIH HHS K01-AG073584 (DBA)NIH HHS K01-EB032898 (KGS)NIH HHS R01-AG034962 (ALJ)NIH HHS R01-AG056534 (ALJ)NIH HHS R01-AG059716 (TJH)NIH HHS R01-AG062826 (KAG)NIH HHS R01-AG080821 (MH)NIH HHS R01-EB017230 (BAL)NIH HHS S10 OD021771NIH HHS S10 OD023680NIH HHS S10-OD02380 (Vanderbilt's High-Performance Computer Cluster for Biomedical Research)NIH HHS U19-AG03655 (MA)NIH HHS U24-AG074855 (TJH)NIH HHS UL1-TR000445 (Vanderbilt Clinical Translational Science Award)NIH HHS UL1-TR002243 (Vanderbilt Clinical Translational Science Award)NINDS NIH HHS R25 NS117367NINDS NIH HHS U01 NS100599NINDS NIH HHS UH2 NS100599NINDS NIH HHS UH3 NS100599TJH U24-AG074855Vanderbilt Clinical Translational Science Award UL1-TR000445Vanderbilt Clinical Translational Science Award UL1-TR002243Vanderbilt's High-Performance Computer Cluster for Biomedical Research R01-AG080821Vanderbilt's High-Performance Computer Cluster for Biomedical Research S10-OD023680
Abstract
introductionThe effects of sex and apolipoprotein E (APOE)-Alzheimer's disease (AD) risk factors-on white matter microstructure are not well characterized.
methodsDiffusion magnetic resonance imaging data from nine well-established longitudinal cohorts of aging were free water (FW)-corrected and harmonized. This dataset included 4741 participants (age = 73.06 ± 9.75) with 9671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FA
resultsSex differences in FA DISCUSSION: There are prominent differences in white matter microstructure by sex and APOE ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted. HIGHLIGHTS: Sex and apolipoprotein E (APOE) ε4 carrier status relate to white matter microstructural integrity. Females generally have lower free water-corrected fractional anisotropy compared to males. APOE ε4 carriers tended to have higher free water than non-carriers.
Indexed as
AgingAlzheimer DiseaseApolipoprotein E4BrainSex CharacteristicsWhite MatterAgedAged, 80 and overAllelesAnisotropyCohort StudiesDiffusion Magnetic Resonance ImagingFemaleHumansLongitudinal StudiesMaleApolipoprotein E4agingAlzheimer's diseasesex differenceswhite matter disease
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