Evidence map›Paper›PMID 39711043›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2025

Metabolic Stress Expands Polyfunctional, Proinflammatory Th

Carmel B Stober, Louise Ellis, Jane C Goodall, Marc Veldhoen, J S Hill Gaston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carmel B StoberUniversity of Cambridge and Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.ORCID 0000-0003-2454-7716
Louise EllisUniversity of Cambridge, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Jane C GoodallUniversity of Cambridge, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
Marc VeldhoenGIMM - Gulbenkian Institute for Molecular Medicine, Avenida Prof. Egas Moniz, Lisbon, Portugal.
J S Hill GastonUniversity of Cambridge, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.

Funding

Cambridge Arthritis Research EndeavourEuropean Research Council Grant 280307-Epithelial_ImmunolNational Institute for Health and Care Research NIHR2046the European Union H2020 ERA project 667824-EXCELLtoINNOVVersus Arthritis 19639
6 · The paper itself

Abstract

objectiveGenetic associations and blockade of the interleukin (IL)-23/IL-17 axis with monoclonal antibodies support a role for this pathway in patients with psoriatic arthritis (PsA). This study examines the requirement of IL-23 for IL-17 production and the role of the metabolic microenvironment in the expansion of Th

methodsTh

resultsPolyfunctional positive IL-17 (IL-17

conclusionWe confirmed the abundance of polyfunctional type 17 CD4 and CD8 cells in the inflamed joints of patients with PsA. We demonstrate IL-23-independent expansion of Th

Indexed as

Arthritis, PsoriaticInterleukin-17Interleukin-23Stress, PhysiologicalTh17 CellsAdultAgedCD8-Positive T-LymphocytesCell DifferentiationFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansInterferon-gammaMaleMiddle AgedSynovial FluidGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaInterleukin-17Interleukin-23

Identifiers

PMID39711043
PMCPMC12209755

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.