Evidence map›Paper›PMID 39710823›Full record

ArticleMolecular neurobiology2025

Overexpression of Heme Oxygenase 1 Enhances the Neuroprotective Effects of Exosomes in Subarachnoid Hemorrhage by Suppressing Oxidative Stress and Endoplasmic Reticulum Stress.

Qiongqiong Gao, Zhumin Su, Xiangxiong Pang, Jinshuo Chen, Ruixiang Luo, Xiaoyang Li, Chi Zhang, Yun Zhao

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiongqiong Gao *Department of neurology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.ORCID http://orcid.org/0000-0001-8029-6398
Zhumin Su *Department of neurology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.
Xiangxiong Pang *Translational Medicine Research Center, Zhujiang Hospital of Southern Medical University, Guangzhou, 510282, China.
Jinshuo ChenCentral Laboratory, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.
Ruixiang LuoCentral Laboratory, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.
Xiaoyang LiCentral Laboratory, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.
Chi ZhangCentral Laboratory, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China. zhangch356@mail.sysu.edu.cn.
Yun ZhaoDepartment of neurology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China. zhaoy379@mail3.sysu.edu.cn.ORCID http://orcid.org/0009-0008-8891-3088

Funding

National Natural Science Foundation of China 8210081National Natural Science Foundation of China 82402954Science Technology Bureau of Wenzhou Y2020298
6 · The paper itself

Abstract

aimsThis study aims to elucidate the therapeutic effects and underlying mechanisms of exosomes derived from Heme oxygenase 1 (HO-1)-overexpressing human umbilical cord mesenchymal stem cells (Exo

methodsIn this study, exosomes were identified using Western blotting, particle analysis, and transmission electron microscopy. The effect of Exo

resultsHO-1-overexpressing human umbilical cord mesenchymal stem cells encapsulated HO-1 into their exosomes. Exo

conclusionExo

Indexed as

Endoplasmic Reticulum StressExosomesHeme Oxygenase-1Neuroprotective AgentsOxidative StressSubarachnoid HemorrhageAnimalsApoptosisHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLNeuronsUmbilical CordHeme Oxygenase-1Neuroprotective AgentsEndoplasmic reticulum stressExosomesHO-1Oxidative stressSubarachnoid hemorrhage

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.