ArticleMikrochimica acta2024
Determination of size and particle number concentration of metallic nanoparticles using isotope dilution analysis combined with single particle ICP-MS to minimise matrix effects.
Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in ICP-MS-Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis.Journal of separation science · 2025Pooled it
- A Simple Online Internal Standard Calibration Strategy for Single-Particle Inductively Coupled Plasma Mass Spectrometry Based on Multielement Analysis.Analytical chemistry · 2025Article
- Exploring environmental nanobiogeochemistry using field-flow fractionation and ICP-MS-based tools: background and fundamentals.Environmental science. Nano · 2025Review
- Ions with Ions, Entities with Entities: A Proof-of-Concept Study Using the SELM-1 Yeast Certified Reference Material for Intra- and Extracellular Se Quantification via Single-Cell ICP-Mass Spectrometry.Analytical chemistry · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is a powerful tool for metallic nanoparticle (NP) characterisation in terms of concentration and, taking into account several assumptions, also size. However, this technique faces challenges, such as the intrinsic matrix effect, which significantly impact the results when analysing real complex samples. This issue is critical for the calculations of key SP-ICP-MS parameters ultimately altering the final outcomes. Novel analytical approaches with high metrological quality such as isotope dilution analysis (IDA) can overcome these limitations by improving signal discrimination in challenging SP-ICP-MS scenarios. This alternative has mainly been applied for NP size characterisation but remains underexplored in modern ICP-MS and SP set-ups. Thus, the implementation of a revised version of IDA-SP-ICP-MS, including recent advances in quadrupole ICP-MS and SP data processing, which enables reliable NP sizing and counting, would be of utmost interest. In this work, this combination using the species-unspecific IDA mode has been investigated as an alternative to tackle matrix effect caused by complex matrices with platinum NPs as a case study. The optimum ionic tracer concentration has been evaluated for different PtNP sizes, resulting in a range of 500 to 1000 ng L
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.