Evidence map›Paper›PMID 39710764›Full record

ArticlePsychopharmacology2025

Working memory processes and the histamine-3 receptor in schizophrenia: a [

Atheeshaan Arumuham, Ekaterina Shatalina, Matthew M Nour, Mattia Veronese, Ellis Chika Onwordi, Stephen J Kaar, Sameer Jauhar, Eugenii A Rabiner, Oliver D Howes

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Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Atheeshaan ArumuhamDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK. atheeshaan.arumuham@kcl.ac.uk.ORCID http://orcid.org/0000-0001-9018-0305
Ekaterina ShatalinaDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Matthew M NourDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Mattia VeroneseDepartment of Information Engineering, University of Padua, Padua, Italy.
Ellis Chika OnwordiDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Stephen J KaarDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Sameer JauharPsychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, Kings College, London, UK.
Eugenii A RabinerInvicro, London, W12 0NN, UK.
Oliver D HowesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK. oliver.howes@kcl.ac.uk.

Funding

Maudsley Charity 666Medical Research Council MC_A656_5QD30_2135Wellcome TrustWellcome Trust 094849/Z/10/Z
6 · The paper itself

Abstract

rationaleWorking memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclinical data suggest histamine-3 receptor (H3R) expression in cortical pyramidal neurons may have a role in working memory, and post-mortem data has found disruptions of H3R expression in schizophrenia.

objectivesWe examined the role of H3R in vivo to elucidate its role on working memory impairment in schizophrenia.

methodsWe used positron emission tomography (PET) with the selective H3R radioligand [

resultsPatients with schizophrenia showed a strong positive correlation, after corrections for multiple comparisons, between ACC H3R availability and task performance (rho = 0.73, p = 0.007), which was absent in the control group (rho = 0.03, p = 0.94). Further ROI analysis did not find a significant relationship between H3R availability and working memory-evoked brain activation.

conclusionsThese results provide support for the role of H3R on working memory processes in patients with schizophrenia.

Indexed as

Memory, Short-TermReceptors, Histamine H3SchizophreniaAdultBrainCarbon RadioisotopesCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyCarbon RadioisotopesReceptors, Histamine H3Cognitive impairmentFMRIH3RHistamineNeuroimagingPETSchizophreniaWorking memory

Identifiers

PMID39710764
PMCPMC12084182

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.