Evidence map›Paper›PMID 39710705›Full record

ArticleJournal of nanobiotechnology2024

Bright NIR-II emissive cyanine dye-loaded lipoprotein-mimicking nanoparticles for fluorescence imaging-guided and targeted NIR-II photothermal therapy of subcutaneous glioblastoma.

Haiyan Huang, Menlong Li, Jingsi Gu, Shubham Roy, Jian Jin, Ting Kuang, Yinghe Zhang, Genwen Hu, Bing Guo

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haiyan HuangSchool of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Menlong LiSchool of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Jingsi GuEducation Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen, 518055, China.
Shubham RoySchool of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Jian JinEducation Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen, 518055, China.
Ting KuangEducation Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen, 518055, China.
Yinghe ZhangSchool of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China.
Genwen HuDepartment of Radiology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China. hugenwen@163.com.
Bing GuoSchool of Science, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, Shenzhen, 518055, China. guobing2020@hit.edu.cn.

Funding

"Chunhui Plan" cooperative scientific research project of the Ministry of Education, China HZKY20220312General project of Guangdong Natural Science Foundation 2022A1515011781Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application ZDSYS20220527171407017Special Foundation for General Basic Research Program of Shenzhen JCYJ20210324132816039the General projects of the National Natural Science Foundation of China 62374080
6 · The paper itself

Abstract

Cyanine dye-containing nanoparticles have widely been used in "all-in-one" NIR fluorescence imaging (FI)-guided photothermal therapy (PTT) because of their intrinsically large extinction coefficient and available physical and chemical modulation methods to tune absorption and emission wavelengths. The combination of good brightness and excellent tumor-targeting capacity is the key to realize efficient NIR-II FI-guided PTT. In this study, by covalently decorating NIR-II absorptive cyanine dyes with bulky AIE motify, we demonstrate how steric hindrance suppresses π-π stacking-induced fluorescence quenching and contributes to the good brightness of NIR-II FI of subcutaneous glioblastoma. The resulting cyanine dye (C

Indexed as

CarbocyaninesGlioblastomaLiposomesNanoparticlesOptical ImagingPhotothermal TherapyAnimalsCell Line, TumorFluorescent DyesHumansMiceMice, Inbred BALB CMice, NudePhototherapyCarbocyaninesFluorescent DyesLiposomesFluorescence imaging in the second near-infrared windowGlioblastomaLipoproteinsPhotothermal therapyTheranostics

Identifiers

PMID39710705
PMCPMC11665114

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.