ArticleBMC cardiovascular disorders2024
Temporal variations in QTc interval during and after COVID-19 infection: a retrospective study.
Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveThe aim of this study was to investigate the dynamic changes in QTc interval duration among patients with COVID-19 infection before, during, and after infection, in order to assess the short- and potential long-term impact of COVID-19 on cardiac electrophysiology.
methodsA retrospective analysis was conducted on 303 inpatients diagnosed with COVID-19 who visited a tertiary Grade A hospital in China between August 2022 and December 2023. Inclusion criteria required patients to have at least two electrocardiogram (ECG) recordings at three specific time points: before COVID-19 infection, during acute infection, and after recovery (more than one month post-infection).
resultsThe mean age of participants was 72.8 ± 14.7 years, with a male preponderance (62%, n = 188). A significant prolongation of QTc interval was observed during COVID-19 infection compared to pre-infection levels (438.3 ± 26.7 ms vs. 433.9 ± 26.6 ms, p = 0.025). QTc interval was positively correlated with age both before (r = 0.23, p = 0.001) and during infection (r = 0.19, p = 0.001). In short-term follow-up (≤ 6 months), QTc interval remained unchanged from the infectious period (p > 0.05), whereas it significantly decreased during long-term follow-up (> 6 months; 429.6 ± 32.5 ms vs. 437.5 ± 28.2 ms, p = 0.002). Additionally, P-wave duration significantly decreased from the infectious period to long-term follow-up (99.5 ± 14.8 ms to 96.4 ± 15.2 ms, p = 0.024).
conclusionsCOVID-19 infection demonstrated a significant correlation with prolonged QTc interval, persisting in the short term but gradually returning to normal in the long term. Similarly, P-wave duration shortened over time, suggesting potential cardiac electrophysiological recovery. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.