Evidence map›Paper›PMID 39710099›Full record

ArticleExperimental eye research2025

Testosterone promotes photoreceptor degeneration in the sodium iodate model.

Timothy T Lee, Brent A Bell, Ying Song, Joshua L Dunaief

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Timothy T LeeFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Brent A BellFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Ying SongFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Joshua L DunaiefFM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address: jdunaief@pennmedicine.upenn.edu.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Retinal Iron Transport in Health and DiseaseR01EY015240 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2004 to 2026
$10.4M
The IL-6 Induced Retinal Iron Sequestration ResponseR01EY028916 · NEI · UNIVERSITY OF PENNSYLVANIA · PI DUNAIEF, JOSHUA L · 2019 to 2023
$2.4M
Development of Two Novel AMD Models for Evaluation of RPE Protection by the Novel Antioxidant D-DHAR01EY036292 · NEI · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA L DUNAIEF · 2024 to 2026
$1.3M
Spectralis Tracking HRA-Optical Coherence Tomography 2 (OCT2): Advanced Ophthalmic Imaging for Small and Large Animal StudiesS10OD026860 · OD · UNIVERSITY OF PENNSYLVANIA · PI BENNETT, JEAN · 2019 to 2019
$239k
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY015240NEI NIH HHS R01 EY028916NEI NIH HHS R01 EY036292NIH HHS S10 OD026860
6 · The paper itself

Abstract

Previously, we found that retinas of young male mice were more damaged than those of young female mice in the sodium iodate (NaIO

Indexed as

IodatesPhotoreceptor Cells, VertebrateRetinal DegenerationTestosteroneAnimalsDisease Models, AnimalElectroretinographyMaleMiceMice, Inbred C57BLReal-Time Polymerase Chain ReactionRhodopsinRNA, MessengerTomography, Optical CoherenceIodatesRhodopsinRNA, Messengersodium iodateTestosterone

Identifiers

PMID39710099
PMCPMC11798707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.