ReviewCardiorenal medicine2025
The Role of Wnt3a/β-Catenin/TCF7L2 Pathway in Diabetes and Cardiorenal Complications.
Review in Cardiorenal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Wnt3a Downregulation Contributes to Type 2 Diabetes Mellitus by Impairing Pancreatic β-Cell Function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Cellular signaling crosstalk between osteoporosis and diabetes: Common mechanisms and therapeutic targets (Review).Biomedical reports · 2026Review
- Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures.Genome biology · 2026Article
- Wnt Signaling-Related Biomarkers in Gestational Diabetes Mellitus: Diagnostic Performance and Integrated Statistical Modeling.Diagnostics (Basel, Switzerland) · 2026Article
- Gene polymorphisms and occurrence of type 2 diabetes in a Gabonese population.International journal of biochemistry and molecular biology · 2026Article
- Naphthoquinones mediate differentiation of human umbilical cord derived mesenchymal stem cells into insulin producing cells through regulation of Wnt and BMP pathways.BioImpacts : BI · 2026Article
- Enhanced diagnostic accuracy of type 1 diabetes mellitus through the combined use of serum β-catenin and HbA1c.Irish journal of medical science · 2025Article
- The association of TCF7L2 gene polymorphisms, rs12255372 and rs7903146, with type 2 diabetes mellitus in the Jordanian population.Molecular biology reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is a prevalent chronic disease that is becoming increasingly common worldwide and can lead to a number of dangerous complications. The Wnt signaling pathway is important for the onset and progression of diabetes. Wnt3a is a typical Wnt ligand that can increase the stability of β-catenin, control TCF7L2 expression, promote β-cell proliferation, and reduce apoptosis. SUMMARY: The involvement of the Wnt3a/β-catenin/TCF7L2 signaling pathway in the development of diabetes and associated problems related to the kidneys is reviewed in this article. KEY MESSAGE: We believe that a thorough comprehension of the molecular connections between diabetes and signaling pathways will eventually lead to improved diabetes management.
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Registered trials
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