Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Cuihua XiaMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0002-6915-3385
Ney Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8594-5676
Carol A TammingaDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6366-5697
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5945-888X
Godfrey D PearlsonDepartments of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Sarah K KeedyDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
Brett ClementzDepartments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
Jennifer E McDowellDepartments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
David ParkerDepartments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
Rebekka LencerInstitute for Translational Psychiatry, Münster University, Münster, Germany.ORCID 0000-0003-4032-7297
S Kristian HillDepartment of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA.
Jeffrey R BishopDepartment of Experimental and Clinical Pharmacology and Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7653-8980
Elena I IvlevaDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
Cindy WenInterdepartmental Program in Bioinformatics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-8747-8231
Rujia DaiDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA.
Chao ChenMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. chenchao@sklmg.edu.cn.ORCID 0000-0002-5114-2282
Chunyu LiuMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. LiuCh@upstate.edu.ORCID 0000-0002-5986-4415
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA. egershon@bsd.uchicago.edu.ORCID 0000-0003-4818-8631
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Stability of Biotypes: a Longitudinal Evaluation (STABLE)R01MH103368 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S, KEEDY, SARAH K · 2015 to 2019
$4.5M
2/2-Discovery and validation of neuronal enhancers associated with the development of psychiatric disordersU01MH116489 · NIMH · UNIVERSITY OF CHICAGO · PI GAYNOR, SOPHIA, GESCHWIND, DANIEL H · 2018 to 2022
$4.5M
5/5 BIPOLAR-SCHIZOPHRENIA NETWORK FOR INTERMEDIATE PHENOTYPES (B-SNIP) - Resubmission - 1R01MH103366 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A, GIBBONS, ROBERT D · 2015 to 2019
$3.8M
Gene Expression Regulation in Brains of East Asian, African, and European Descent Explains Schizophrenia GWAS in Diverse Populations.R01MH126459 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI Chunyu Liu · 2022 to 2026
$3.7M
Psychosis-related Physiological and Neuronal Phenotypes in 22q11 Deletion SyndromeR01MH117315 · NIMH · EMORY UNIVERSITY · PI CUBELLS, JOSEPH F., DUNCAN, ERICA J · 2019 to 2023
$3.4M
1/2 Measuring translational dynamics and the proteome to identify potential brain biomarkers for psychiatric diseaseR01MH110920 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU · 2016 to 2019
$2.0M
COLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Ancestry-Adjusted PRSs (AAPRSs), which allow for PRS analysis of multi-ancestry samples. Applied to schizophrenia PRS, we found the Khera AAPRS method to show superior portability and comparable prediction accuracy as compared with the Ge method. The three Biotypes of psychosis disorders had similar AAPRSs across ancestries. In genomic analysis of Biotypes, 12 genes, and isoforms showed significant genomic associations with specific Biotypes in a Transcriptome-Wide Association Study (TWAS) of genetically regulated expression (GReX) in the adult brain and fetal brain. TWAS inflation was addressed by the inclusion of genotype principal components in the association analyses. Seven of these 12 genes/isoforms satisfied Mendelian Randomization (MR) criteria for putative causality, including four genes TMEM140, ARTN, C1orf115, CYREN, and three transcripts ENSG00000272941, ENSG00000257176, ENSG00000287733. These genes are enriched in the biological pathways of Rearranged during Transfection (RET) signaling, Neural Cell Adhesion Molecule 1 (NCAM1) interactions, and NCAM signaling for neurite out-growth. The specific associations with Biotypes suggest that pharmacological clinical trials and biological investigations might benefit from analyzing Biotypes separately.
Indexed as
Psychotic DisordersAdultBipolar DisorderBrainFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansMaleMendelian Randomization AnalysisMultifactorial InheritancePhenotypePolymorphism, Single NucleotideRisk FactorsSchizophrenia
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations. · full record | OpenQuestion