Evidence map›Paper›PMID 39709402›Full record

Trial reportBMC oral health2024

Evaluation of leukocyte-platelet rich fibrin as an antibiotic slow-release biological device in the treatment of moderate periodontitis: a randomized controlled clinical trial.

Yasmeen K Omar, Mohy A El Rashidy, Ghada B Ahmed, Aliaa G Aboulela

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06153706 (Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06153706 phase2 / phase3completednot on this map

Evaluation of L-PRF as an Antibiotic Slow-release Biological Device in the Treatment of Moderate Periodontitis (A Randomized Controlled Clinical Trial)

TypeinterventionalSponsorYasmeen KhaledRan2022 to 2023Enrolled24ConditionsPeriodontitisArmsSubgingival application of L-PRF loaded with metronidazole, Subgingival application of L-PRF
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yasmeen K OmarDepartment of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Champollion St, Azarita, 21527, Alexandria, Egypt. yasmeen.khaled.dent@alexu.edu.eg.
Mohy A El RashidyDepartment of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Champollion St, Azarita, 21527, Alexandria, Egypt.
Ghada B AhmedDepartment of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Faculty of Dentistry, Alexandria University, Champollion St, Azarita, 21527, Alexandria, Egypt.
Aliaa G AboulelaDepartment of Microbiology, Medical Research Institute, Alexandria University, Azarita, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriodontitis is a chronic inflammatory disease caused by the accumulation of biofilm. Antimicrobials have been used as adjuncts to non-surgical periodontal therapy. However, systemic antibiotics often require large dosages to achieve suitable concentrations at the disease site. Leukocyte platelet-rich fibrin (L-PRF) is a promising bio-material, with antimicrobial, anti-inflammatory, and wound-healing enhancement effects. This study aimed to evaluate the efficacy of L-PRF as a locally sustained released device for metronidazole antimicrobial.

methodsTwenty-four patients with eighty periodontal pockets had moderate periodontitis with attachment loss of 3-4 mm, and probing depth ≤ 5, which was equally divided into two groups: Group (I) underwent scaling and root planing with intra-pocket application of L-PRF loaded with Metronidazole, while Group (II) was treated by scaling and root planing with intra-pocket application of L-PRF alone. Microbiological measurements were taken at baseline and after one month to analyze the relative count of Porphyromonas gingivalis (P. gingivalis) using real time PCR. Clinical parameters were measured at baseline and after 1, 3, and 6 months. These parameters included probing depth (PD), clinical attachment loss (CAL), plaque index (PI), modified gingival index (MGI), and bleeding index (BI).

resultsMicrobiological and clinical findings revealed that both treatment methods resulted in a reduction in P. gingivalis counts, in addition to improvements in the clinical parameters: PD reduction, CAL gain, PI reduction, BI decrease and MGI reduction compared to baseline. However, L-PRF-metronidazole group showed superior results in the studied parameters over the study period. Nonetheless, there was no statistically significant improvement. (p < .001).

conclusionThe intra-pocket application of both L-PRF loaded with Metronidazole and L-PRF alone contributed to the successful treatment of moderate periodontitis.

trial registrationNCT06153706 ( http://www.clinical-trials.gov/ ); 1/12/2023, retrospective registration.

Indexed as

MetronidazolePeriodontitisPlatelet-Rich FibrinPorphyromonas gingivalisAdultAnti-Bacterial AgentsDelayed-Action PreparationsDental ScalingFemaleHumansLeukocytesMaleMiddle AgedPeriodontal IndexPeriodontal PocketRoot PlaningAnti-Bacterial AgentsDelayed-Action PreparationsMetronidazoleAntibacterial agentsIntrasulcular fluidLeukocyte and platelet-rich fibrin (L-PRF)Metronidazole

Identifiers

PMID39709402
PMCPMC11662799

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.