Evidence map›Paper›PMID 39709380›Full record

ArticleBMC oral health2024

Dynamic effects of fixed orthodontic treatment on oral health and oral microbiota: a prospective study.

Mei Zhao, Chaoran Yu, Chengjun Su, Haiyan Wang, Xiaoyu Wang, Michael D Weir, Hockin H K Xu, Min Liu, Yuxing Bai, Ning Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mei Zhao *School of Stomatology, Capital Medical University, Beijing, 100050, China.
Chaoran Yu *School of Stomatology, Capital Medical University, Beijing, 100050, China.
Chengjun SuSchool of Stomatology, Capital Medical University, Beijing, 100050, China.
Haiyan WangDepartment of Stomatology, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, China.
Xiaoyu WangDepartment of Stomatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100070, China.
Michael D WeirDepartment of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD, 21201, USA.
Hockin H K XuDepartment of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD, 21201, USA.
Min LiuSchool of Stomatology, Capital Medical University, Beijing, 100050, China.
Yuxing BaiSchool of Stomatology, Capital Medical University, Beijing, 100050, China. byuxing@ccmu.edu.cn.
Ning ZhangSchool of Stomatology, Capital Medical University, Beijing, 100050, China. dentistzhang112@163.com.

Funding

Beijing Municipal Administration of Hospitals Incubating Program PX2022062Innovation Research Team Project of Beijing Stomatological Hospital, Capital Medical University CXTD202203
6 · The paper itself

Abstract

objectiveThis prospective clinical study examined the effects of fixed orthodontic appliances on oral hygiene and assessed changes in the oral microflora structure of orthodontic patients using high-throughput sequencing technology.

methodsA total of 45 patients undergoing initial fixed orthodontic treatment were recruited from three hospitals in Beijing, China. Clinical parameters and oral hygiene habits questionnaire were recorded at pre-treatment (T0) and at a 6-month follow-up (T1). Saliva samples were collected for DNA extraction, PCR amplification, 16S rRNA gene sequencing, and bioinformatics analysis. Microbial diversity and structural changes in abundance were evaluated.

resultsAfter six months of orthodontic treatment, patients' daily brushing frequency increased (P ≤ 0.01), while the plaque index and the debris index decreased. A total of 3,344,549 valid tags were obtained from 90 saliva samples. After the six-month follow-up, the microbial diversity in patients' saliva samples increased significantly. High-throughput sequencing identified 3,662 amplicon sequence variants (ASVs), with the dominant phyla being Proteobacteria, Bacteroidota, Firmicutes, Actinobacteriota, Fusobacteriota, Patescibacteria, Campylobacterota and Spirochaetota. At the phylum level, the abundance of Firmicutes_C and Spirochaetota at T1 significantly increased compared to T0.

conclusionDuring fixed orthodontic treatment, although patients' oral hygiene habits improved, significant changes in the oral microbiota structure were still observed, with an increase in anaerobic and pathogenic bacteria that may potentially impact oral health.

Indexed as

MicrobiotaOral HealthOrthodontic Appliances, FixedSalivaAdolescentAdultFemaleHigh-Throughput Nucleotide SequencingHumansMaleMouthOral HygieneProspective StudiesRNA, Ribosomal, 16SYoung AdultRNA, Ribosomal, 16S16S rRNA high-throughput sequencingEnamel demineralizationMicrobiological analysisMicrobiotaOrthodontic appliances

Identifiers

PMID39709380
PMCPMC11662850

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.