Evidence map›Paper›PMID 39709337›Full record

Trial reportBMC anesthesiology2024

Inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of anesthesia and postoperative impact on mental health status: a prospective, single-center, randomized controlled trial.

Ju Qian, Yan Peng, YiQun Mao, FuHai Ji, XiSheng Shan, Jing Cheng, Shuang Zhou

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ju QianDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yan PengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. jasminedj1982@126.com.
YiQun MaoDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
FuHai JiDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
XiSheng ShanDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jing ChengDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Shuang ZhouDepartment of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Funding

Health Talent Plan Project in Suzhou GSWS2022007
6 · The paper itself

Abstract

backgroundIntravenous administration of sufentanil during anesthesia induction induces cough (SIC), sometimes triggers a severe reaction. We wanted to investigate the inhibitory effect of low-dose esketamine on cough induced by sufentanil during the induction of general anesthesia, as well as its postoperative impact on mental status (MMSE score, RSS, and VAS-A).

methodsA total of 256 adult patients were randomly allocated to receive either esketamine (Group EK) or normal saline (Group C). One minute before the administration of sufentanil, Group EK and Group C were injected with esketamine (0.05 mg/kg, diluted with normal saline to 3 ml) and normal saline (3 ml), respectively. The primary outcomes were the incidence (the basis of the presence or absence of cough) and severity (the frequency of cough episodes) of cough within 2 min after sufentanil injection.The secondary outcomes included hemodynamic variables (MAP, HR, and SPi), mental status (MMSE score, RSS, and VAS-A) and postoperative events (time to awareness, duration of orientation recovery and degree of satisfaction with anesthesia).

resultsA total of 236 adult patients were randomized into two groups (n = 236): Group EK (n = 118) and Group C (n = 118). The incidence of cough in Group EK (21.2%) was significantly lower than that in Group C (40.7%) (P < 0.05). The incidence rates for each grade were as follows: 9.3% and 16.9% for Grade 2, and 0% and 4.2% for Grade 3, respectively.The differences had statistical senses.The MAP and HR at T4 (during tracheal intubation) and T5 (1 min post-intubation) were significantly lower in Group EK (P < 0.05). There were no significant differences in MMSE score, RSS, and VAS-A, time to awareness, duration of orientation recovery or satisfaction with anesthesia.

conclusionPretreatment with low-dose esketamine can reduce the incidence and severity of cough induced by sufentanil and maintain hemodynamic stability during anesthesia induction without increasing mental status (MMSE score, RSS, and VAS-A).

trial registrationChinese Clinical Trial Registry (ChiCTR2400084940, date of registration: 05/28/2024).

Indexed as

CoughKetamineSufentanilAdultAnesthesia, GeneralAnesthetics, IntravenousDouble-Blind MethodFemaleHumansMaleMental HealthMiddle AgedProspective StudiesAnesthetics, IntravenousEsketamineKetamineSufentanilCoughEketamineGeneral anesthesiaInductionMental systemPretreatmentSufentanil

Identifiers

PMID39709337
PMCPMC11662481

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.