Evidence map›Paper›PMID 39709175›Full record

ArticleResuscitation2025

Left ventricular energetics in patients receiving veno-arterial extracorporeal membrane oxygenation for extracorporeal cardiopulmonary resuscitation.

Rajat Kalra, Christopher Gaisendrees, Tamas Alexy, Marinos Kosmopoulos, Sebastian Voicu, Jason A Bartos, Sergey G Gurevich, Ganesh Raveendran, Deborah Jaeger, Despoina Koukousaki and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Immediate post-ECPR management strategies in the prehospital and critical care transport medicine environments.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rajat KalraCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Christopher GaisendreesCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Cardiothoracic Surgery, University Hospital of Cologne, Germany.
Tamas AlexyCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Marinos KosmopoulosCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA; Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA.
Sebastian VoicuCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA; Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, Université Paris Cité, INSERM UMR-S 1144, Paris, France.
Jason A BartosCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Sergey G GurevichCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Ganesh RaveendranCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Deborah JaegerCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA; INSERM U 1116, University of Lorraine, Vandoeuvre-lès-Nancy, France.
Despoina KoukousakiCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Andrea M ElliottCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Alejandra Gutierrez BernalCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA.
Mark DennisDepartment of Cardiology, Royal Prince Alfred Hospital, Faculty of Medicine and Health, University of Sydney, Australia; Sydney Medical School, Sydney University, Sydney, NSW, Australia.
Brian BurnsSydney Medical School, Sydney University, Sydney, NSW, Australia; Trauma Service, Royal North Shore Hospital, Reserve Rd, St Leonards, Sydney, NSW, Australia; Aeromedical Operations, NSW Ambulance, Sydney, NSW, Australia; Faculty of Medicine, Macquarie University, Sydney, NSW, Australia.
Demetris YannopoulosCardiovascular Division, University of Minnesota, Minneapolis, MN, USA; Center for Resuscitation Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address: yanno001@umn.edu.

Funding

Left ventricular physiological effects of veno-arterial ECMO support during cardiogenic shockR01HL160973 · NHLBI · UNIVERSITY OF MINNESOTA · PI YANNOPOULOS, DEMETRIS · 2022 to 2025
$2.7M
NHLBI NIH HHS R01 HL160973
6 · The paper itself

Abstract

introductionThe haemodynamic effects veno-arterial extracorporeal membrane oxygenation (VA-ECMO) remain inadequately understood. We investigated invasive left ventricular (LV) haemodynamics in patients who underwent treatment with an intensive care strategy involving extracorporeal cardiopulmonary resuscitation (ECPR).

methodsWe conducted invasive haemodynamic assessments on 15 patients who underwent ECPR and achieved return of spontaneous circulation. Left ventricular end-diastolic pressure (LVEDP), ejection fraction (LVEF), end-diastolic volume (LVEDV), and stroke work (LVSW) were evaluated using simultaneous invasive left heart catheterization and 3D echocardiography. Paired comparisons between high and low VA-ECMO flow were performed.

resultsInvasive haemodynamic studies were performed in 15 patients aged 58 (43,65) years at 3.0 (2.0, 4.0) days after cannulation. Six patients survived the index hospitalization, and 9 expired during the index hospitalization. Among the total cohort, transitioning from the highest VA-ECMO flow (median 4.0 L/min) to the lowest VA-ECMO flow (median 2.0 L/min) led to increases in LVEDV from 85 (68,125) mL to 106 (70,153) mL (p = 0.005) and LVEDP from 14 (8,23) mmHg to 17 (12,30) mmHg (p = 0.001), respectively. Similarly, the LVSW increased from 2051 ± 1525 mL*mmHg at the highest level of VA-ECMO flow to 2627 ± 1559 at the lowest VA-ECMO flow (p = 0.01).

conclusionHigh VA-ECMO flow significantly reduced LVEDP, LVEDV, and LVSW compared to low VA-ECMO flow.

Indexed as

Cardiopulmonary ResuscitationExtracorporeal Membrane OxygenationHeart ArrestVentricular Function, LeftAdultAgedCardiac CatheterizationEchocardiographyFemaleHemodynamicsHumansMaleMiddle AgedStroke VolumeExtracorporeal cardiopulmonary resuscitationHaemodynamicsVA-ECMO

Identifiers

PMID39709175
PMCPMC11842208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.