Evidence map›Paper›PMID 39708817›Full record

ArticleImmunity2025

Deep profiling deconstructs features associated with memory CD8

Milcah C Scott, Zoë Steier, Mark J Pierson, J Michael Stolley, Stephen D O'Flanagan, Andrew G Soerens, Sathi P Wijeyesinghe, Lalit K Beura, Gayathri Dileepan, Brandon J Burbach and 8 more

Abstract read
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. A Gene-Program Architecture of Mouse T cells.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Article
  14. BHLHE40 Orchestrates Effector Tissue-Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  15. Origins of CD8 tissue resident memory.Frontiers in immunology · 2026
    Review
  16. Article
  17. Tissue-resident memory T cells reshapeFrontiers in immunology · 2026
    Review
  18. Article
  19. Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Milcah C ScottDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Zoë SteierMassachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
Mark J PiersonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
J Michael StolleyDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen D O'FlanaganDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Andrew G SoerensDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Sathi P WijeyesingheDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Lalit K BeuraDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Gayathri DileepanDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Brandon J BurbachDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Marco KünzliDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Clare F QuarnstromDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Olivia C Ghirardelli SmithDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Eyob WeyuDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Sara E HamiltonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Vaiva VezysDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Alex K ShalekMassachusetts Institute of Technology, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
David MasopustDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: masopust@umn.edu.

Funding

Mucosal T Cell Memory to PathogensR01AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI MASOPUST, DAVID · 2010 to 2023
$5.8M
Resident Memory T CellsR01AI146032 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2020 to 2026
$3.8M
Minnesota Training Program in VirologyT32AI083196 · NIAID · UNIVERSITY OF MINNESOTA · PI Louis M Mansky · 2010 to 2026
$3.2M
New mouse model to better predict human immunity to influenza vaccination and infectionR01AI150600 · NIAID · UNIVERSITY OF MINNESOTA · PI LANGLOIS, RYAN, MASOPUST, DAVID · 2021 to 2024
$2.5M
Mucosal T cell memory to pathogensR37AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2024 to 2026
$1.7M
Regulation and Function of Oral Resident Memory T CellsK99DE031014 · NIDCR · UNIVERSITY OF MINNESOTA · PI STOLLEY, JAMES MICHAEL · 2021 to 2022
$213k
Investigating the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skinF30AI181450 · NIAID · UNIVERSITY OF MINNESOTA · PI Olivia C. Smith · 2024 to 2026
$160k
Investigating the Abundance, Fate, and Function of Secondary Lymphoid Organ Resident Memory T cellsF31AI176750 · NIAID · UNIVERSITY OF MINNESOTA · PI O'FLANAGAN, STEPHEN D · 2023 to 2024
$69k
Defining tissue specific phenotypes that faithfully identify tissue resident memory T cellsF31AI152353 · NIAID · UNIVERSITY OF MINNESOTA · PI SCOTT, MILCAH C · 2021 to 2022
$65k
NIAID NIH HHS F30 AI181450NIAID NIH HHS F31 AI152353NIAID NIH HHS F31 AI176750NIAID NIH HHS R01 AI084913NIAID NIH HHS R01 AI146032NIAID NIH HHS R01 AI150600NIAID NIH HHS R37 AI084913NIAID NIH HHS T32 AI083196NIDCR NIH HHS K99 DE031014
6 · The paper itself

Abstract

Tissue-resident memory CD8

Indexed as

CD8-Positive T-LymphocytesImmunologic MemoryMemory T CellsAnimalsCell DifferentiationMiceMice, Inbred C57BLParabiosisSingle-Cell Analysisantigen persistenceCD69cell markersCITE-seqdirty miceinfectionmemory CD8(+) T cellsmigrationtissue-resident memory T cells

Identifiers

PMID39708817
PMCPMC11852946

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.