Evidence map›Paper›PMID 39708432›Full record

ArticlePediatric neurology2025

Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children.

Allyssa M Mattes, Renée A Shellhaas, Hannah C Glass, Julie Sturza, Stephanie Rau, Monica Lemmon, Elizabeth E Rogers, Adam Numis, Janet S Soul, Madison Berl and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Allyssa M MattesDivision of Rehabilitation Psychology Neuropsychology, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan; New Day Neuropsychology LLC, Noblesville, Indiana.
Renée A ShellhaasDepartment of Neurology, Washington University in St Louis School of Medicine, St. Louis, Missouri.
Hannah C GlassDepartment of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, California; Department of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, California.
Julie SturzaDepartment of Pediatrics, University of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Stephanie RauDivision of Rehabilitation Psychology Neuropsychology, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan.
Monica LemmonDepartments of Pediatrics and Population Health Sciences, Duke University, School of Medicine, DUMC 3710, Durham, North Carolina.
Elizabeth E RogersDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, California.
Adam NumisDepartment of Neurology and Weill Institute for Neuroscience, University of California, San Francisco, California; Department of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, California.
Janet S SoulDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Madison BerlDivision of Neuropsychology, Children's National Hospital, Washington, District of Columbia.
Courtney J WusthoffDepartment of Neurology, University of California Davis, Davis, California.
Catherine J ChuDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Shavonne L MasseyDepartment of Neurology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Cameron ThomasDivision of Neurology, Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Linda S FranckDepartment of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, California.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, California.
Guilia M BenedettiDepartment of Pediatrics, University of Michigan, Michigan Medicine, Ann Arbor, Michigan.
Justin MeansNSR Parent Partner, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Katie MeansNSR Parent Partner, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Tayyba AnwarDivision of Neuropsychology, Children's National Hospital, Washington, District of Columbia.
Jennifer C Gidley LarsonDivision of Rehabilitation Psychology Neuropsychology, Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan. Electronic address: jlarso@med.umich.edu.

Funding

Neonatal Seizure Registry Developmental Functional EValuation (NSR-DEV)R01NS111166 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GLASS, HANNAH CRANLEY, SHELLHAAS, RENEE A. · 2020 to 2023
$4.6M
NSR-GENE (Neonatal Seizure Registry, GEnetics of post-Neonatal Epilepsy)R01NS124051 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hannah Cranley Glass · 2022 to 2026
$3.3M
NINDS NIH HHS R01 NS111166NINDS NIH HHS R01 NS124051
6 · The paper itself

Abstract

backgroundNeonatal seizures are common with acute brain injury. Up to 25% of survivors develop postneonatal epilepsy. We hypothesized postneonatal epilepsy diagnosed by age 24 months would increase risk for early markers of neurobehavioral disorders than acute provoked neonatal seizures alone.

methodsNeonates with acute provoked seizures born from July 2015 to March 2018 were enrolled at nine Neonatal Seizure Registry sites. Composite scores from parent-completed standardized ratings assessed Adaptive, Social, Externalizing, Internalizing, Self-Regulation, and Sensory Seeking domains. Linear regression demonstrated relationships between composite scores for children who developed postneonatal epilepsy compared with those who did not. Results were adjusted for seizure etiology, sex, gestational age, and cerebral palsy (CP) severity.

resultsA total of 151 children (n = 20, 13% with postneonatal epilepsy), 4.1 years median age, participated. Children with epilepsy had impaired adaptive (Cohen d = 1.62, P < 0.0001), social (Cohen d = 0.86, P = 0.004), and executive functioning (Cohen d = 0.56, P = 0.06) compared with children without epilepsy. Mean scores for children without epilepsy were within average range. Risk for impairment among children with epilepsy persisted after adjusting for neonatal seizure etiology, sex, and gestational age, but not when adjusting for CP severity.

conclusionsThere was higher incidence of adverse neurobehavioral outcomes among preschool children diagnosed with postneonatal epilepsy compared with those without epilepsy. CP severity was associated with greater impairment; results also suggest that epilepsy is an independent predictor of adaptive functioning. Children with postneonatal epilepsy should be screened for neurobehavioral problems to facilitate early identification and developmental support.

Indexed as

EpilepsySeizuresChild, PreschoolFemaleHumansInfantInfant, NewbornMaleRegistriesAdaptive functioningBehaviorDevelopmentEpilepsyNeonatal seizureNeurobehavioral profilesSocial skills

Identifiers

PMID39708432
PMCPMC13296877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.