ArticleEBioMedicine2025
3D ultrasound localization microscopy of the nonhuman primate brain.
Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Fast 3-D Ultrasound Localization Microscopy via Projection-Based Processing Framework.IEEE transactions on medical imaging · 2026Article
- Voice-controlled super-resolution ultrasound imaging and reporting powered by multimodal large language models.NPJ digital medicine · 2026Article
- Real-time volumetric imaging of cells and molecules in deep tissues with Takoyaki ultrasound.Nature communications · 2026Article
- Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs.Nature communications · 2025Article
- In Vivo Dynamic Coronary Arteries Blood Flow Imaging Based on Multi-Cycle Phase Clustering Ultrafast Ultrasound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy.Science advances · 2025Article
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- Ultrasound Super-Resolution Imaging of Neonatal Cerebral Vascular Reorganization.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Transcranial ultrasound localization microscopy in moyamoya patients using a clinical ultrasound system.Theranostics · 2025Article
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7 authors.
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Abstract
backgroundHaemodynamic changes occur in stroke and neurodegenerative diseases. Developing imaging techniques allowing the in vivo visualisation and quantification of cerebral blood flow would help better understand the underlying mechanism of these cerebrovascular diseases.
methods3D ultrasound localization microscopy (ULM) is a recently developed technology that can map the microvasculature of the brain at large depth and has been mainly used until now in rodents. In this study, we tested the feasibility of 3D ULM of the nonhuman primate (NHP) brain with a single 256-channel programmable ultrasound scanner.
findingsWe achieved a highly resolved vascular map of the macaque brain at large depth (down to 3 cm) in presence of craniotomy and durectomy using an 8-MHz multiplexed matrix probe. We were able to distinguish vessels as small as 26.9 μm. We also demonstrated that transcranial imaging of the macaque brain at similar depth was feasible using a 3-MHz probe and achieved a resolution of 60 μm.
interpretationThis work paves the way to clinical applications of 3D ULM. In particular, transcranial 3D ULM in humans could become a tool for the non-invasive study and monitoring of the brain cerebrovascular changes occurring in neurological diseases.
fundingThis work was supported by the New Frontier in Research Fund (NFRFE-2022-00590), by the Canada Foundation for Innovation under grant 38095, by the Natural Sciences and Engineering Research Council of Canada (NSERC) under discovery grant RGPIN-2020-06786, by Brain Canada under grant PSG2019, and by the Canadian Institutes of Health Research (CIHR) under grant PJT-156047 and MPI-452530. Computing support was provided by the Digital Research Alliance of Canada.
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