Evidence map›Paper›PMID 39708401›Full record

ArticleJournal of geriatric oncology2025

The pervasive impact of frailty on ovarian cancer care and the role of prehabilitation: Qualitative perspectives of key stakeholders.

Stephanie Cham, Rachel A Pozzar, Neil Horowitz, Colleen Feltmate, Ursula A Matulonis, Jennifer C Lai, Alexi A Wright

Abstract read
In one paragraph

Article in Journal of geriatric oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie ChamDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology & Reproductive Sciences, University of California San Francisco, San Francisco, CA, United States. Electronic address: stephanie.cham@ucsf.edu.
Rachel A PozzarDana Farber Cancer Institute, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Neil HorowitzDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Colleen FeltmateDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Ursula A MatulonisDana Farber Cancer Institute, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Alexi A WrightDana Farber Cancer Institute, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

Funding

WOMEN'S REPRODUCTIVE HEALTH RESEARCH CENTERK12HD001262 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Andrea Vashti Jackson · 1998 to 2026
$9.3M
The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular CarcinomaK24AG080021 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2023 to 2026
$755k
Promoting gynecologic cancer patients with frailty to achieve functional recovery cohort study (PROOF Cohort Study)R03AG088902 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAM, STEPHANIE · 2024 to 2024
$350k
NIA NIH HHS K24 AG080021NIA NIH HHS R03 AG088902NICHD NIH HHS K12 HD001262
6 · The paper itself

Abstract

introductionWe performed a qualitative study to explore key stakeholders' perspectives about the impact of frailty on ovarian cancer care and evaluate a candidate prehabilitation intervention. MATERIALS AND

methodsWe conducted semi-structured interviews with patient-caregiver dyads and multi-disciplinary clinicians. Patients were ≥ 50 years of age with a new diagnosis of advanced stage (III/IV) ovarian cancer who received cancer-directed treatment (chemotherapy and/or surgery) during the past year and met criteria as pre-frail or frail using the FRAIL scale. We used a semi-structured interview guide to elicit participants' views on frailty, nutrition, physical therapy, and a candidate prehabilitation intervention. We used inductive and deductive approaches to code and analyze interviews and identify emergent themes and patterns.

resultsTen patients and caregivers (five dyads) and 10 providers were interviewed. We identified four themes: (1) frailty screening is essential to prevent over- and under-treatment, but underused; (2) stakeholders preferred a multidisciplinary approach to providing tailored care for frail patients over a candidate prehabilitation intervention; (3) patient, family caregiver, and clinician stakeholders reported multiple barriers to prehabilitation programs, including concerns about selection bias, and (4) frail patients and family members are vulnerable and require more psychosocial support. DISCUSSION: We identified significant barriers to prehabilitation interventions for frail patients with ovarian cancer; initiatives to increase frailty screening and provide tailored multi-disciplinary approaches may have a greater impact.

Indexed as

Frail ElderlyFrailtyOvarian NeoplasmsAgedAged, 80 and overCaregiversFemaleHumansInterviews as TopicMiddle AgedQualitative ResearchChemotherapyFrailtyOvarian cancerPrehabilitationQualitative researchSurgery

Identifiers

PMID39708401
PMCPMC12476166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.