Evidence map›Paper›PMID 39708372›Full record

ArticleMolecular biology and evolution2024

MEGA12: Molecular Evolutionary Genetic Analysis Version 12 for Adaptive and Green Computing.

Sudhir Kumar, Glen Stecher, Michael Suleski, Maxwell Sanderford, Sudip Sharma, Koichiro Tamura

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,159 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,159citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,159 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. One health (Amsterdam, Netherlands) · 2026
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  11. Adaptive landscape and genetic divergence of Karnah sheep revealed by selection scans across multiple ovine breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
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  15. Article
  16. Article
  17. Review
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  20. Article

1,099 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sudhir KumarInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-9918-8212
Glen StecherInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
Michael SuleskiInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
Maxwell SanderfordInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
Sudip SharmaInstitute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-0469-1211
Koichiro TamuraDepartment of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan.ORCID 0000-0001-7189-5399

Funding

Methods For Evolutionary Genomics AnalysisR35GM139540 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI Sudhir Kumar · 2021 to 2026
$2.9M
NIGMS NIH HHS R35 GM139540NIH HHS R35GM139540-04
6 · The paper itself

Abstract

We introduce the 12th version of the Molecular Evolutionary Genetics Analysis (MEGA12) software. This latest version brings many significant improvements by reducing the computational time needed for selecting optimal substitution models and conducting bootstrap tests on phylogenies using maximum likelihood (ML) methods. These improvements are achieved by implementing heuristics that minimize likely unnecessary computations. Analyses of empirical and simulated datasets show substantial time savings by using these heuristics without compromising the accuracy of results. MEGA12 also links-in an evolutionary sparse learning approach to identify fragile clades and associated sequences in evolutionary trees inferred through phylogenomic analyses. In addition, this version includes fine-grained parallelization for ML analyses, support for high-resolution monitors, and an enhanced Tree Explorer. MEGA12 can be downloaded from https://www.megasoftware.net.

Indexed as

Evolution, MolecularSoftwareLikelihood FunctionsModels, GeneticPhylogenybootstrapgreen computingmodel selectionphylogenomicssoftware

Identifiers

PMID39708372
PMCPMC11683415

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.