Evidence map›Paper›PMID 39708274›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Multiple regional outbreaks caused by global and local VIM-producing Klebsiella pneumoniae clones in Poland, 2006-2019.

Marta Biedrzycka, Paweł Urbanowicz, Sylvain Brisse, Federica Palma, Dorota Żabicka, Marek Gniadkowski, Radosław Izdebski

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Encoding Genes of Metallo β-Lactamases (Health science reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marta BiedrzyckaDepartment of Molecular Microbiology, National Medicines Institute, Warsaw, Poland.ORCID http://orcid.org/0000-0002-9590-658X
Paweł UrbanowiczDepartment of Molecular Microbiology, National Medicines Institute, Warsaw, Poland.ORCID http://orcid.org/0000-0001-8622-706X
Sylvain BrisseBiodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-2516-2108
Federica PalmaBiological Resource Center of the Institut Pasteur, Institut Pasteur, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-7865-961X
Dorota ŻabickaDepartment of Epidemiology and Clinical Microbiology, National Medicines Institute, Warsaw, Poland.ORCID http://orcid.org/0000-0001-9386-8885
Marek GniadkowskiDepartment of Molecular Microbiology, National Medicines Institute, Warsaw, Poland.ORCID http://orcid.org/0000-0003-2981-4721
Radosław IzdebskiDepartment of Molecular Microbiology, National Medicines Institute, Warsaw, Poland. r.izdebski@nil.gov.pl.ORCID http://orcid.org/0000-0003-1195-9471

Funding

Polish National Science Centre 2019/33/B/NZ7/01461
6 · The paper itself

Abstract

purposeThis study was aimed at comprehensive genomic analysis of VIM-type carbapenemase-producing Klebsiella pneumoniae species complex (KpSC) in Poland.

methodsAll non-duplicate 214 VIM-producing KpSC isolates reported in Poland in 2006-2019 were short-read sequenced and re-identified by the average nucleotide identity scoring. Their clonality/phylogeny was assessed by cgMLST and SNP in comparison with genomes from international databases. Serotypes, VIM-encoding integrons, resistomes, virulomes and plasmid replicons were identified by various bioinformatic tools. Structures of plasmids and genomic islands with VIM integrons were analysed for representative long-read sequenced isolates.

resultsThe KpSC isolates were the second most prevalent VIM-positive Enterobacterales (23.1%) in Poland in 2006-2019, following Enterobacter spp. (40.1%). Their significance emerged in 2014 and then grew consequently, owing to eight regional outbreaks of K. pneumoniae sequence types (STs) ST437, ST147, ST15, ST277 and ST392. These carried different VIM integrons, mainly In238 and In916 types, located on IncFIB + IncHI2 (pNDM-MAR)-, IncA- or IncM-like plasmids, or clc-type integrative and conjugative elements. Despite relatedness of the outbreak clusters to isolates from other countries, e.g. Greece, Spain, Slovakia or Germany, most of them have apparently emerged on site by horizontal acquisition of resistance determinants from other species, including Enterobacter spp. and Pseudomonas spp.

conclusionsThis work shows dynamic epidemiology of VIM-producing organisms, driven by a mix of circulation of different VIM-encoding elements, and parallel clonal spread of multiple organisms.

Indexed as

beta-LactamasesDisease OutbreaksKlebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial ProteinsGenome, BacterialHumansIntegronsMicrobial Sensitivity TestsPhylogenyPlasmidsPolandAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesKlebsiella pneumoniaeKpSCPolandST147ST437VIM

Identifiers

PMID39708274

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