Trial reportPlant foods for human nutrition (Dordrecht, Netherlands)2024
The Acute Ingestion of Yerba Mate (Ilex paraguariensis) Infusion Does Not Modify Endothelial Function, Hemodynamics, or Heart Rate Variability: A Randomized Crossover Clinical Trial.
Trial report in Plant foods for human nutrition (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Yerba Maté and its impact on glycemic control and metabolic health: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Cardiometabolic Effects of Ilex paraguariensis (Yerba Mate): A Narrative Review of Evidence and Research Gaps.Cureus · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsHerbal plants may contribute to reducing the incidence of cardiovascular disease. Yerba mate (YM) emerges as a candidate to improve endothelial function, hemodynamics, and heart rate variability (HRV) due to its antioxidant and anti-inflammatory properties, potentially decreasing cardiovascular risk. Therefore, studies are needed to assess the effect of YM ingestion on these parameters. This study aimed to evaluate the impact of acute ingestion of YM infusion (hot or cold) on endothelial function, hemodynamics, and HRV. METHODS AND
resultsIn this crossover randomized clinical trial, 13 participants (18-40 years old) of both genders were evaluated under three conditions: control (water), cold YM infusion, and hot YM infusion. The primary outcome was endothelial function assessed through flow-mediated dilation (FMD), with the secondary outcomes including blood pressure (BP), heart rate (HR) and HRV. Parameters were evaluated before and after intervention (40' and 80'). Analysis of variance (ANOVA) showed an intervention effect on FMD (%) (p < 0.05), with both cold and hot YM associated to higher FMD% compared to control, although no time or time*intervention effects were found. ANOVA also showed a time effect on BP, HR, and HRV time and frequency domains variables (p < 0.05), though no time*intervention or intervention effect was observed.
conclusionWe did not find acute effects of YM infusion on endothelial function, central hemodynamic, or autonomic parameters in healthy adults. These results were not impacted by the temperature of YM. Further studies should assess the dose-response of acute and chronic YM ingestion on endothelial function.
trial registrationU1111-1289-9324, retrospectively registered in May 2023.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.