Evidence map›Paper›PMID 39708219›Full record

ArticleDiscover oncology2024

Geneticsbiologiesingle cell and expression analysis for erectile dysfunction and cervical cancer targets.

Tengfei Zhao, Yangyang Li, Huixue Liu, Chongxin Tong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tengfei ZhaoObstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China.
Yangyang LiObstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China.
Huixue LiuObstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China.
Chongxin TongObstetrics and Gynecology Department of Hebei Children's Hospital, Shijiazhuang, 050000, Hebei, China. youxiang1631202409@163.com.

Funding

Hebei Province Medical Science Research Project Plan No.20220751
6 · The paper itself

Abstract

backgroundSexual dysfunction and cervical cancer are genetically and molecularly two complex health problems. Here, we integrate genetic inference and single-cell expression analysis to identify potential genetic targets for sexual dysfunction and cervical cancer, and assess causality of these targets utilizing Mendelian randomization approaches.

methodsWe performed a genome-wide association study (GWAS) to identify genetic variants associated with sexual dysfunction and cervical cancer. Next, we examined the cellular landscape of these variation regions based on scRNAseq data.

resultsThe study identified several genetic variants that are correlated with sexual dysfunction and cervical cancer, respectively, and these differentially expressed in reproductive and cervical cells. Two-Gene Combination Panel Increased expression of the WISP1 gene was detected in cervical cancer tissues. Twas most highly expressed in T cells, and least well- when cells were proliferating.

conclusionsThe study integrates genetics with single-cell expression to nominate genetic targets for sexual dysfunction and cervical cancer and establishes causal support from Mendelian randomization approach.

Indexed as

Cervical cancerGenetic inferencePotential targetSexual dysfunctionSingle cell expression analysis

Identifiers

PMID39708219
PMCPMC11663209

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.