Evidence map›Paper›PMID 39708215›Full record

ArticleGeroScience2025

A unique inflammaging profile generated by T cells from people with obesity is metformin resistant.

S SantaCruz-Calvo, S Saraswat, G H Kalantar, E Zukowski, H Marszalkowski, A Javidan, F Gholamrezaeinejad, L P Bharath, P A Kern, X D Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CytokineProfile: An Integrated Web Tool for Cytokine Profiling Analysis.Computational and structural biotechnology journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

S SantaCruz-CalvoDepartment of Pharmacology & Nutritional Sciences, Diabetes and Obesity Research Priority Area, University of Kentucky, Lexington, KY, USA.ORCID 0000-0001-6037-8986
S SaraswatDepartment of Biostatistics, University of Kentucky, Lexington, KY, USA.
G H KalantarDepartment of Microbiology, Immunology & Molecular Genetics, University of Kentucky, Lexington, KY, USA.
E ZukowskiDepartment of Nutrition & Public Health, Merrimack College, North Andover, MA, USA.
H MarszalkowskiDepartment of Biology, Merrimack College, North Andover, MA, USA.
A JavidanDepartment of Pharmacology & Nutritional Sciences, Diabetes and Obesity Research Priority Area, University of Kentucky, Lexington, KY, USA.
F GholamrezaeinejadDepartment of Pharmacology & Nutritional Sciences, Diabetes and Obesity Research Priority Area, University of Kentucky, Lexington, KY, USA.
L P BharathDepartment of Nutrition & Public Health, Merrimack College, North Andover, MA, USA.
P A KernDepartment of Internal Medicine, University of Kentucky, Lexington, KY, USA.
X D ZhangDepartment of Biostatistics, University of Kentucky, Lexington, KY, USA.
B S NikolajczykDepartment of Pharmacology & Nutritional Sciences, Diabetes and Obesity Research Priority Area, University of Kentucky, Lexington, KY, USA. barb.nik@uky.edu.ORCID 0000-0001-5647-5740

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRAINING PROGRAM IN OXIDATIVE STRESS AND NUTRITIONT32DK007778 · NIDDK · UNIVERSITY OF KENTUCKY · PI WEBB, NANCY R · 2000 to 2019
$2.5M
Restoration of Impaired Awareness of Hypoglycemia U01 Consortium: University of KentuckyU01DK135111 · NIDDK · UNIVERSITY OF KENTUCKY · PI SIMON J FISHER · 2022 to 2026
$2.3M
The impact of insulin sensitivity on the potential of metformin to delay age-related inflammationR01AG079525 · NIA · UNIVERSITY OF KENTUCKY · PI NIKOLAJCZYK, BARBARA · 2022 to 2025
$2.3M
Mitochondrial Aging Promotes InflammationR15AG068957 · NIA · MERRIMACK COLLEGE · PI PANNEERSEELAN-BHARATH, LEENA · 2021 to 2025
$868k
OLD AGE MORTALITY PATTERNS IN DEVELOPED COUNTRIESR01AG006985 · NIA · UNIVERSITY OF PENNSYLVANIA · PI PRESTON, SAMUEL H · 1987 to 1988
–
Basic Research Laboratory P30CA177558Division of Diabetes, Endocrinology, and Metabolic Diseases 1U01DK135111Division of Diabetes, Endocrinology, and Metabolic Diseases T32DK007778NCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NIA NIH HHS 1R01AG079525NIA NIH HHS R01 AG079525NIA NIH HHS R15 AG068957NIA NIH HHS R15AG068957NIA NIH HHS R56AG06985NIDDK NIH HHS P30 DK020579NIDDK NIH HHS T32 DK007778NIDDK NIH HHS U01 DK135111NIGMS NIH HHS UL1TR001998
6 · The paper itself

Abstract

The alarmingly high prevalence of obesity in older adults coupled with the negative health effects of chronic inflammation in both obesity and aging highlight the importance of studies investigating the impacts of obesity on age-related inflammation. Since shifts in peripheral T-cell metabolism and function drive systemic inflammation in both obesity and aging, we hypothesize that obesity impacts the Th17-dominated inflammaging profile we identified in lean subjects and thus modifies the anti-inflammatory effects of geroprotective drugs like metformin. New cytokine profiling data showed that CD4

Indexed as

AgingHypoglycemic AgentsInflammationMetforminObesityT-LymphocytesAgedAutophagyBody Mass IndexCD4-Positive T-LymphocytesCytokinesFemaleHumansMaleMiddle AgedReactive Oxygen SpeciesCytokinesHypoglycemic AgentsMetforminReactive Oxygen SpeciesAge-related inflammationAutophagyPartial least squares discriminant analysisRedox balanceSystemic inflammation

Identifiers

PMID39708215
PMCPMC12181501

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.