Evidence map›Paper›PMID 39708204›Full record

ArticleDiscover oncology2024

Impact of gout on colorectal cancer and its survival: a two-sample Mendelian randomization study.

Li-Qiang Wei, Yi-Bei Song, Dong Lan, Xue-Jing Miao, Chun-Yu Lin, Shu-Ting Yang, Deng-He Liu, Xiao-Jv Chi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li-Qiang Wei *Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Yi-Bei Song *Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Dong LanDepartment of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Xue-Jing MiaoDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Chun-Yu LinDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Shu-Ting YangDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Deng-He LiuDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China. liudenghe@sr.gxmu.edu.cn.
Xiao-Jv ChiDepartment of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Key Laboratory of Clinical Laboratory Medicine of Guangxi Department of Education, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, China. chixiaojv@gxmu.edu.cn.

Funding

the Clinical Research"Climbing" Program of the First Affiliated Hospital of Guangxi Medical University YYZS2020023the Guangxi Health Department Research Project z20190853the Guangxi Health Department Research Project Z-A20230495the Promoting Project of Basic Capacity for Young and Middle-aged University Teachers in Guangxi 2020KY03016
6 · The paper itself

Abstract

backgroundThe relationship between gout and colorectal cancer (CRC) remains unclear, emphasizing the need for additional research to clarify the potential cumulative effect of gout on CRC development.

methodsLeveraging a single nucleotide polymorphism-based genome-wide association study, the potential causal correlation between gout and CRC was initially analyzed using Mendelian randomization (MR). Subsequently, our analysis was expanded to include an assessment of patient survival, with the aim of evaluating the potential causal correlation between gout and CRC and the impact of gout on CRC survival outcomes.

resultsAccording to MR findings, a substantial relationship was observed between gout and the incidence of CRC when CRC was used as the outcome (OR = 0.954, 95% CI = 0.915-0.995). These results indicate a negative relationship between gout and the likelihood of developing CRC. In addition, when evaluating the overall survival (OS) or cancer-specific survival (CSS) of patients with CRC as outcomes, gout exhibited a significant relationship with survival. The inverse variance weighting approach demonstrated a progressive enhancement in CRC survival with the cumulative impact of gout (OS: OR = 2.000 × 10

conclusionAs gout accumulates, it exerts an inhibitory influence on CRC, indicating a potential protective effect. This study provides robust evidence that can guide the development of future clinical treatment approaches and research priorities.

Indexed as

Cancer-specific survivalColorectal cancerGoutMendelian randomizationOverall survival

Identifiers

PMID39708204
PMCPMC11663203

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.