Evidence map›Paper›PMID 39708200›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2024

Modulation of Inflammation Levels and the Gut Microbiota in Mice with DSS-Induced Colitis by a Balanced Vegetable Protein Diet.

Qiqi Sun, Zhenfeng Yu, Lei Luo, Sen Li, Xiao Guan, Zhenliang Sun

Abstract read
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In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiqi Sun *School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Zhenfeng Yu *Shanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, 201499, China.
Lei LuoSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.
Sen LiSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. lisen_1027@126.com.
Xiao GuanSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. gnxo@163.com.
Zhenliang SunShanghai University of Medicine & Health Sciences Affiliated Sixth People's Hospital South Campus, Shanghai, 201499, China. zhenliang6@126.com.

Funding

Scientific Research Foundation of SUMHS SSF-23-15-001Shanghai Feng Xian District Science and Technology Project 2023the National Key R&D Program of China 2022YFF1100104the National Natural Science Foundation 81872418the Science and Technology Commission of Shanghai Municipality 21S11902000
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a nonspecific chronic inflammatory disease of the intestine that is mainly divided into ulcerative colitis and Crohn's disease. Nutrients play important roles in the treatment of IBD. In this study, the effects of vegetable proteins on the regulation of IBD were explored via the amino acid scoring formula. Two diets with different amino acid scores, a balanced one and an imbalanced one, were assessed for their effects on acute colitis induced by dextran sodium sulfate (DSS). Pathological symptoms were evaluated by the disease activity index (DAI) and hematoxylin-eosin (H&E) staining, the expression of inflammatory factors and barrier proteins was determined via qPCR and western blotting, and the intestinal microbiota was examined via 16 S rRNA sequencing. The results indicated that the balanced vegetable protein diet (BVPD) relieved colitis by reducing the colonic histological score, inhibiting the expression of proinflammatory factors such as IL-1β, IL-6, and TNF-α and promoting the expression of tight junction proteins. Analysis of gut microbes revealed that the BVPD altered the structural composition of the intestinal flora in animals with DSS-induced colitis by increasing the abundance of beneficial bacteria (Lactobacillus, Bifidobacterium, etc.). In conclusion, a BVPD effectively relieves colitis and may be a promising adjuvant strategy for the treatment of IBD.

Indexed as

ColitisDextran SulfateGastrointestinal MicrobiomePlant Proteins, DietaryAmino AcidsAnimalsColonDietDisease Models, AnimalInflammationInflammatory Bowel DiseasesInterleukin-1betaInterleukin-6MaleMiceMice, Inbred C57BLAmino AcidsDextran SulfateInterleukin-1betaInterleukin-6Plant Proteins, DietaryTight Junction ProteinsTumor Necrosis Factor-alphaBalanced vegetable protein dietColitisGut microbiotaInflammationNutrition

Identifiers

PMID39708200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.