Evidence map›Paper›PMID 39708190›Full record

ArticleProbiotics and antimicrobial proteins2025

The Efficacy of Cecropin Against Multidrug-Resistant Bacteria Is Linked to the Destabilization of Outer Membrane Structure LPS of Gram-Negative Bacteria.

Luying Sun, Minyi Jia, Kui Zhu, Zhihui Hao, Jianzhong Shen, Shaolin Wang

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Luying SunNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Minyi JiaTechnology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya, China.
Kui ZhuNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Zhihui HaoNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Jianzhong ShenNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Shaolin WangNational Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China. shaolinwang@cau.edu.cn.

Funding

Hong Kong Special Administrative Region, China T11-104/22-RNational Key R&D Funding of China 2023YFE0199500Pinduoduo-China Agricultural University Research Fund PC2023A01002
6 · The paper itself

Abstract

The escalating prevalence of antibiotic-resistant bacteria has emerged as a formidable threat to global health, and the quest for alternative antimicrobial agents is imperative. Cecropins, a class of antimicrobial peptides (AMPs), have garnered attention due to their potent bactericidal properties. This investigation delves into the antibacterial prowess of Cecropin A (CA) and Cecropin AD (CAD), showcasing their robust activity against Gram-negative bacteria, inclusive of multidrug-resistant bacteria. The bactericidal efficacy of CA and CAD is characterized by a dose-responsive paradigm, affirming their potential as therapeutic agents. These peptides exhibit minimal cytotoxicity and hemolytic effects, underscoring their safety profile. Advanced experimentation has elucidated that cecropins could disrupt the outer bacterial membrane, targeting lipid A, a pivotal constituent of the lipopolysaccharides (LPS) in the outer membrane as their antimicrobial bullseye. The affinity of cecropins for LPS and their antimicrobial action underscore the therapeutic potential of these peptides in targeting Gram-negative bacterial infections. These insights accentuate the promise of cecropins as viable "antibiotic substitutes," paving the path for their expanded application in combating antibiotic resistance.

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesBacterial Outer MembraneCecropinsDrug Resistance, Multiple, BacterialGram-Negative BacteriaLipopolysaccharidesAnimalsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptidescecropin ACecropinsLipopolysaccharidesCecropinGram-negative bacteriaLipopolysaccharidesMultidrug-resistant bacteria

Identifiers

PMID39708190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.