Evidence map›Paper›PMID 39708175›Full record

ArticleCancer immunology, immunotherapy : CII2024

Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy.

S J Luk, M E IJsselsteijn, A Somarakis, I Acem, I Briaire de Bruijn, K Szuhai, J V M G Bovee, N F C C de Miranda, J H F Falkenburg, M H M Heemskerk

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

S J LukDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands. s.j.luk@lumc.nl.
M E IJsselsteijnDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
A SomarakisDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
I AcemDepartment of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
I Briaire de BruijnDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
K SzuhaiDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.
J V M G BoveeDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
N F C C de MirandaDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
J H F FalkenburgDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
M H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, The Netherlands. m.h.m.heemskerk@lumc.nl.

Funding

Leids Universitair Medisch Centrum MD/PhD Grand 2018
6 · The paper itself

Abstract

Synovial sarcoma is an aggressive soft-tissue cancer that shows limited responses to current immunotherapeutic approaches using immune checkpoint blockade or adoptive cell therapy. To improve immunotherapy for this cancer, understanding how the immune cells in the tumor microenvironment associate with histological subtype, disease progression and current therapies is vital. To evaluate the immune infiltrate in synovial sarcoma in relation to histological subtype, disease progression and in response to cytotoxic treatment, we performed immunodetection of T cells, CD68

Indexed as

ImmunotherapySarcoma, SynovialAdolescentAdultAgedFemaleHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedMyeloid CellsT-LymphocytesTumor MicroenvironmentYoung AdultAdoptive T-cell therapyImmunotherapySarcomaSurvivalSynovial sarcomaT-cell therapy

Identifiers

PMID39708175
PMCPMC11663204

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.